2-(3-phenyl-1,2,4-oxadiazol-5-yl)quinoline | 1430731-77-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-(3-phenyl-1,2,4-oxadiazol-5-yl)quinoline
• 英文别名: 3-phenyl-5-(quinolin-2-yl)-1,2,4-oxadiazole；3-Phenyl-5-quinolin-2-yl-1,2,4-oxadiazole；3-phenyl-5-quinolin-2-yl-1,2,4-oxadiazole
• CAS: 1430731-77-3
• 化学式: C₁₇H₁₁N₃O
• 分子量: 273.294
• InChiKey: MGDKTRNRKGSYMY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  51.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  苯甲酰胺肟 在 N,N'-羰基二咪唑 、 sodium hydroxide 作用下， 以 二甲基亚砜 为溶剂， 反应 20.5h， 生成 2-(3-phenyl-1,2,4-oxadiazol-5-yl)quinoline
  参考文献：
  名称：

  容易从室温获得的1,2,4-恶二唑核的组装，该酰胺由现成的a胺肟和羧酸制成

  摘要：

  报道了在超碱促进条件下从a胺肟和羧酸合成3,5-二取代-1,2,4-恶二唑的一锅法环境温度程序。

  DOI：

  10.1016/j.tetlet.2018.06.019

文献信息

• Novel Method of Synthesizing Various Five Membered Heterocycles from an Aryl Tribromomethyl Group
  作者：Robert Tynebor、Elizabeth Millings

  DOI：10.1080/00397911.2012.679331

  日期：2013.7.18

  Synthesis of five membered heterocycles from an aryl tribromomethyl functional group is discussed. Exposing a tribromomethyl group to subsequent nucleophilic attacks by a 1,2-di-nucleophilic species promotes the cyclization of five membered heterocycles. Such heterocycles as oxadiazoles, thiadiazole, benzimidazole, benzothioazole, and benzoxazole were synthesized in moderate to good yields. Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications (R) to view the free supplemental file.
• Facile room-temperature assembly of the 1,2,4-oxadiazole core from readily available amidoximes and carboxylic acids
  作者：Tatyana Sharonova、Vitalina Pankrat'eva、Polyna Savko、Sergey Baykov、Anton Shetnev

  DOI：10.1016/j.tetlet.2018.06.019

  日期：2018.7

  A one-pot ambient-temperature procedure for the synthesis of 3,5-disubstituted-1,2,4-oxadiazoles from amidoximes and carboxylic acids under superbase-promoted conditions is reported.

  报道了在超碱促进条件下从a胺肟和羧酸合成3,5-二取代-1,2,4-恶二唑的一锅法环境温度程序。