(E)-N-((1H-indol-3-yl)methylene)-4-chlorobenzenamine | 1304495-82-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: (E)-N-((1H-indol-3-yl)methylene)-4-chlorobenzenamine
• CAS: 1304495-82-6
• 化学式: C₁₅H₁₁ClN₂
• 分子量: 254.719
• InChiKey: OOQDVATVUWHSHC-RQZCQDPDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.57
• 重原子数：
  18.0
• 可旋转键数：
  2.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  28.15
• 氢给体数：
  1.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  (E)-N-((1H-indol-3-yl)methylene)-4-chlorobenzenamine 、 巯基乙酸 以66%的产率得到
  参考文献：
  名称：

  Bhatt J. J., Shah B. R., Shah H. P., Trivedi P. B., Undavia N. K., Desai +, Indian. J. Chem. B, 33 (1994) N 2, S 189-192

  摘要：

  DOI：
• 作为产物：
  描述：

  在 sodium nitrite 作用下， 以 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 6.0h， 生成 (E)-N-((1H-indol-3-yl)methylene)-4-chlorobenzenamine
  参考文献：
  名称：

  Synthesis and Evaluation of Schiff’s Base Indole Derivatives Against Inflammation Induced by Carrageenan in Rats

  摘要：

  Inflammation is a complex physiological response that can lead to various health issues. The development of effective anti-inflammatory agents is crucial for managing inflammatory conditions. This study focused on synthesizing and evaluating Schiff's base Indole derivatives for their anti-inflammatory potential. Among several synthesized compounds, C1IN, C2IN, C3IN, C7IN, C8IN, and C11IN demonstrated substantial reductions in paw edema and levels of cytokines of inflammation such as IL-1β and TNF-α. In-silico analysis and molecular docking studies further supported the observed effects, indicating potential interactions with TNF-α. The study highlights the therapeutic potential of Schiff's base Indole derivatives in mitigating inflammatory responses. Hence, Schiff's base Indole derivatives present a novel avenue for future research and the potential development of anti-inflammatory drugs.

  DOI：

  10.13005/ojc/400113

文献信息

• Microwave Assisted Synthesis and Antimicrobial Evaluation of Schiff Bases of Indole-3-aldehyde
  作者：Priyanka Kamaria、N. Kawathekar、Prerna Chaturvedi

  DOI：10.1155/2011/265329

  日期：——

  In order to develop new antimicrobial agents, a series of Schiff bases of indole-3-aldehyde were synthesized by microwave assisted synthesis by takingDMFas solvent and evaluated for their antimicrobial activity. All the synthesized compounds were characterized byIR,¹HNMRand mass spectral analysis. All compounds were tested against five gram positive and five gram negative bacterial strains and one fungal strain. All compounds exhibited better activity against gram positive strains than against gram negative strains and the compounds were found more active againstS.aureusandB.subtilis.

  为了开发新的抗菌剂，通过微波辅助合成合成了一系列吲哚-3-甲醛的席夫碱，以DMF为溶剂，并评估了它们的抗菌活性。所有合成的化合物均通过红外光谱（IR）、质子核磁共振（1H NMR）和质谱分析进行了表征。所有化合物均对五种革兰氏阳性和五种革兰氏阴性细菌菌株以及一种真菌菌株进行了测试。所有化合物对革兰氏阳性菌株的活性优于对革兰氏阴性菌株的活性，而这些化合物对金黄色葡萄球菌（S.aureus）和枯草芽孢杆菌（B.subtilis）的活性更高。
• Binding function 3 (BF3) site compounds as therapeutics and methods for their use
  申请人：THE UNIVERSITY OF BRITISH COLUMBIA

  公开号：US10351527B2

  公开（公告）日：2019-07-16

  This invention provides compound having a structure of Formulas: Uses of such compounds for treatment of various indications, including prostate cancer as well as methods of treatment involving such compounds are also provide.

  本发明提供了具有式结构的化合物：本发明还提供了此类化合物在治疗包括前列腺癌在内的各种适应症方面的用途，以及涉及此类化合物的治疗方法。
• Binding Function 3 (BF3) site compounds as therapeutics and methods for their use
  申请人：THE UNIVERSITY OF BRITISH COLUMBIA

  公开号：US10633338B2

  公开（公告）日：2020-04-28

  This invention provides compound having a structure of Formulas: Uses of such compounds for treatment of various indications, including prostate cancer as well as methods of treatment involving such compounds are also provide.

  本发明提供了具有以下结构式的化合物： 本发明还提供了此类化合物在治疗包括前列腺癌在内的各种适应症方面的用途，以及涉及此类化合物的治疗方法。
• SHAGALOV L. B.; ERAKSINA V. N.; IVANOVA T. M.; CYBOPOB N. N.; MASLENNIKOV+, XIMIYA GETEROTSIKL. SOEDIN., 1979, HO 7, 909-915
  作者：SHAGALOV L. B.、 ERAKSINA V. N.、 IVANOVA T. M.、 CYBOPOB N. N.、 MASLENNIKOV+

  DOI：——

  日期：——
• BINDING FUNCTION 3 (BF3) SITE COMPOUNDS AS THERAPEUTICS AND METHODS FOR THEIR USE
  申请人：THE UNIVERSITY OF BRITISH COLUMBIA

  公开号：US20170029372A1

  公开（公告）日：2017-02-02

  This invention provides compound having a structure of Formulas: Uses of such compounds for treatment of various indications, including prostate cancer as well as methods of treatment involving such compounds are also provide.