(S)-methyl 3-(4-((4-methoxy-3,5-dimethylpyridin-2-yl)methoxy)phenyl)-2-palmitamidopropanoate | 935548-22-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (S)-methyl 3-(4-((4-methoxy-3,5-dimethylpyridin-2-yl)methoxy)phenyl)-2-palmitamidopropanoate
• 英文别名: methyl (2S)-2-(hexadecanoylamino)-3-[4-[(4-methoxy-3,5-dimethylpyridin-2-yl)methoxy]phenyl]propanoate
• CAS: 935548-22-4
• 化学式: C₃₅H₅₄N₂O₅
• 分子量: 582.824
• InChiKey: CFLWIFWDYLYURQ-HKBQPEDESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.9
• 重原子数：
  42
• 可旋转键数：
  23
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.63
• 拓扑面积：
  86.8
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (S)-methyl 3-(4-((4-methoxy-3,5-dimethylpyridin-2-yl)methoxy)phenyl)-2-palmitamidopropanoate 在 sodium tetrahydroborate 、 正丁基锂 、 三甲基溴硅烷 作用下， 以 四氢呋喃 、 乙醇 、 二氯甲烷 为溶剂， 反应 9.0h， 生成 2-hydroxy-4-(4-((4-methoxy-3,5-dimethylpyridin-2-yl)methoxy)phenyl)-3-(S)-palmitamidobutylphosphonic acid
  参考文献：
  名称：

  Synthesis and biological evaluation of phosphonate derivatives as autotaxin (ATX) inhibitors

  摘要：

  Autotaxin (ATX) is an autocrine motility factor that promotes cancer cell invasion, cell migration, and angiogenesis. ATX, originally discovered as a nucleotide phosphodiesterase, is known now to be responsible for the lysophospholipid-preferring phospholipase D activity in plasma. As such, it catalyzes the production of lysophosphatidic acid (LPA) from lysophophatidylcholine (LPC). ATX is thus an attractive drug target; small molecular inhibitors might be efficacious in slowing the spread of cancers. With this study we have generated a series of P-keto and P-hydroxy phosphonate derivatives of LPA, some of which are potent ATX inhibitors. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.12.114
• 作为产物：
  描述：

  L-酪氨酸甲酯盐酸盐 在 18-冠醚-6 、 potassium carbonate 、 三乙胺 作用下， 以 二氯甲烷 、 丙酮 为溶剂， 反应 3.0h， 生成 (S)-methyl 3-(4-((4-methoxy-3,5-dimethylpyridin-2-yl)methoxy)phenyl)-2-palmitamidopropanoate
  参考文献：
  名称：

  Synthesis and biological evaluation of phosphonate derivatives as autotaxin (ATX) inhibitors

  摘要：

  Autotaxin (ATX) is an autocrine motility factor that promotes cancer cell invasion, cell migration, and angiogenesis. ATX, originally discovered as a nucleotide phosphodiesterase, is known now to be responsible for the lysophospholipid-preferring phospholipase D activity in plasma. As such, it catalyzes the production of lysophosphatidic acid (LPA) from lysophophatidylcholine (LPC). ATX is thus an attractive drug target; small molecular inhibitors might be efficacious in slowing the spread of cancers. With this study we have generated a series of P-keto and P-hydroxy phosphonate derivatives of LPA, some of which are potent ATX inhibitors. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.12.114

文献信息

• PHOSPHONATE DERIVATIVES AS AUTOTAXIN INHIBITORS
  申请人：Lynch Kevin R.

  公开号：US20100016258A1

  公开（公告）日：2010-01-21

  The present invention provides β-hydroxy phosphonate compounds that are autotaxin inhibitors.

  本发明提供了一种β-羟基膦酸酯化合物，它们是自动税感受器抑制剂。
• Synthesis and structure–activity relationships of tyrosine-based inhibitors of autotaxin (ATX)
  作者：James E. East、Andrew J. Kennedy、Jose L. Tomsig、Alexandra R. De Leon、Kevin R. Lynch、Timothy L. Macdonald

  DOI：10.1016/j.bmcl.2010.09.030

  日期：2010.12

  Autotaxin (ATX) is a secreted soluble enzyme that generates lysophosphatidic acid (LPA) through its lysophospholipase D activity. Because of LPA's role in neoplastic diseases, ATX is an attractive therapeutic target due to its involvement in LPA biosynthesis. Here we describe the SAR of ATX inhibitor, VPC8a202, and apply this SAR knowledge towards developing a high potency inhibitor. We found that electron density in the pyridine region greatly influences activity of our inhibitors at ATX. (C) 2010 Elsevier Ltd. All rights reserved.
• US8378100B2
  申请人：——

  公开号：US8378100B2

  公开（公告）日：2013-02-19