6-[(S)-1-(tetrahydrofuran-2-yl)methoxy]isochromen-1-one | 947150-44-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 异香豆素及其衍生物
• 英文名称: 6-[(S)-1-(tetrahydrofuran-2-yl)methoxy]isochromen-1-one
• 英文别名: 6-[[(2S)-oxolan-2-yl]methoxy]isochromen-1-one
• CAS: 947150-44-9
• 化学式: C₁₄H₁₄O₄
• 分子量: 246.263
• InChiKey: QGQWMIGHXFADMD-LBPRGKRZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  6-[(S)-1-(tetrahydrofuran-2-yl)methoxy]isochromen-1-one 在 三甲基铝 、 水 、 Rochelle's salt 作用下， 以 二氯甲烷 、 甲苯 为溶剂， 反应 3.25h， 生成 2-[4-((1R,3R,5S)-8-methyl-8-azabicyclo[3.2.1]oct-3-yloxy)phenyl]-6-[(S)-1-(tetrahydrofuran-2-yl)methoxy]-2H-isoquinolin-1-one
  参考文献：
  名称：

  WO2007/93366

  摘要：

  公开号：
• 作为产物：
  描述：

  (S)-(tetrahydrofuran-2-yl)methyl methanesulfonate 、 6-hydroxy-1H-isochromen-1-one 在 caesium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 7.0h， 生成 6-[(S)-1-(tetrahydrofuran-2-yl)methoxy]isochromen-1-one
  参考文献：
  名称：

  NOVEL SUBSTITUTED TETRAHYDRONAPHTHALENES, PROCESS FOR THE PREPARATION THEREOF AND THE USE THEREOF AS MEDICAMENTS

  摘要：

  该发明涉及替代四氢萘及其衍生物，以及与之相关的生理相容盐和生理功能衍生物，其制备方法，包含至少一种创新替代四氢萘或其衍生物的药物，以及将创新替代四氢萘及其衍生物用作药物的用途。

  公开号：

  US20100249097A1

文献信息

• NOVEL AZACYCLYL-SUBSTITUTED ARYLDIHYDROISOQUINOLINONES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS
  申请人：SCHWINK Lothar

  公开号：US20090264403A1

  公开（公告）日：2009-10-22

  The invention relates to azacyclyl-substituted aryldihydroisoquinolinones and their derivatives, and their physiologically tolerated salts and physiologically functional derivatives, their preparation, medicaments comprising at least one azacyclyl-substituted aryldihydroisoquinolinone of the invention or its derivative, and the use of the azacyclyl-substituted aryidihydroisoquinolinones of the invention and their derivatives as MCH antagonists.

  本发明涉及含氮杂环取代的芳基二氢异喹啉酮及其衍生物、其生理上可耐受的盐和生理功能衍生物、其制备方法、包含本发明中至少一种含氮杂环取代的芳基二氢异喹啉酮或其衍生物的药物以及将本发明中的含氮杂环取代的芳基二氢异喹啉酮及其衍生物用作MCH拮抗剂。
• NOVEL AMINOALCOHOL-SUBSTITUTED ARYLDIHYDROISOQUINOLINONES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS
  申请人：SCHWINK Lothar

  公开号：US20090082391A1

  公开（公告）日：2009-03-26

  The invention relates to aminoalcohol-substituted aryldihydroisoquinolinones and their derivatives, and their physiologically tolerated salts and physiologically functional derivatives, their preparation, medicaments comprising at least one aminoalcohol-substituted aryldihydroisoquinolinone of the invention or its derivative, and the use of the aminoalcohol-substituted aryldihydroisoquinolinones of the invention and their derivatives as MCH antagonists.

  本发明涉及氨基醇取代的芳基二氢异喹啉酮及其衍生物，以及其生理耐受盐和生理功能衍生物、其制备方法、至少包含本发明中的一种氨基醇取代的芳基二氢异喹啉酮或其衍生物的药物，以及将本发明中的氨基醇取代的芳基二氢异喹啉酮及其衍生物用作MCH拮抗剂的用途。
• Substituted tetrahydronaphthalenes, process for the preparation thereof and the use thereof as medicaments
  申请人：Schwink Lothar

  公开号：US08609731B2

  公开（公告）日：2013-12-17

  The invention relates to substituted tetrahydronaphthalenes and derivatives thereof, and also to the physiologically compatible salts and physiologically functional derivatives thereof, to preparation thereof, to medicaments comprising at least one inventive substituted tetrahydronaphthalene or derivative thereof, and to the use of the inventive substituted tetrahydronaphthalenes and derivatives thereof as medicaments.

  本发明涉及取代四氢萘及其衍生物，以及其生理相容盐和生理功能衍生物，其制备方法，包含至少一种本发明的取代四氢萘或其衍生物的药物，以及将本发明的取代四氢萘及其衍生物用作药物的用途。
• Azacyclyl-substituted aryldihydroisoquinolinones, process for their preparation and their use as medicaments
  申请人：Schwink Lothar

  公开号：US08822495B2

  公开（公告）日：2014-09-02

  The invention relates to azacyclyl-substituted aryldihydroisoquinolinones and their derivatives, and their physiologically tolerated salts and physiologically functional derivatives, their preparation, medicaments comprising at least one azacyclyl-substituted aryldihydroisoquinolinone of the invention or its derivative, and the use of the azacyclyl-substituted aryldihydroisoquinolinones of the invention and their derivatives as MCH antagonists.

  本发明涉及含氮杂环取代的芳基二氢异喹啉酮及其衍生物，其生理耐受盐和生理功能衍生物，其制备方法，至少包括本发明中的一种含氮杂环取代的芳基二氢异喹啉酮或其衍生物的药物，以及将本发明中的含氮杂环取代的芳基二氢异喹啉酮及其衍生物用作MCH拮抗剂。
• AZACYCLYL-SUBSTITUTED ARYLDIHYDROISOQUINOLINONES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS
  申请人：SANOFI

  公开号：EP1987020B1

  公开（公告）日：2012-10-03