4-methoxyphenyl (2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-(1->3)-[(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-(1->4)]-2-O-acetyl-α-L-rhamnopyranoside | 1192361-00-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-methoxyphenyl (2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-(1->3)-[(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-(1->4)]-2-O-acetyl-α-L-rhamnopyranoside
• CAS: 1192361-00-4
• 化学式: C₄₃H₅₆O₂₅
• 分子量: 972.903
• InChiKey: OURGOMFJBYVUTR-LQOMGINKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.69
• 重原子数：
  68.0
• 可旋转键数：
  18.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  301.31
• 氢给体数：
  0.0
• 氢受体数：
  25.0

反应信息

• 作为反应物：
  描述：

  4-methoxyphenyl (2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-(1->3)-[(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-(1->4)]-2-O-acetyl-α-L-rhamnopyranoside 在 ammonium cerium (IV) nitrate 、 水 作用下， 以 乙腈 为溶剂， 反应 3.0h， 生成
  参考文献：
  名称：

  Total synthesis of the heptasaccharide repeating unit of the iron-binding exopolysaccharide secreted by Klebsiella oxytoca BAS-10

  摘要：

  The first total synthesis of a heptasaccharide found in the iron-binding exopolysaccharide produced by Klebsiella oxytoca BAS-10 has been achieved in excellent yield using a block synthetic strategy. A trisaccharide glycosyl donor was stereoselectively coupled with a tetrasaccharide glycosyl acceptor using the trichloroacetimidate activation procedure. The yields and stereo outcome were excellent in each step of glycosylation. A late stage oxidation protocol was adopted for the oxidation of the primary hydroxyl group to the carboxylic functionality while keeping a secondary hydroxyl group unaffected. (c) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2009.07.009
• 作为产物：
  描述：

  4-methoxyphenyl 2-O-acetyl-α-L-rhamnopyranoside 、 2,3,4,6-四-O-乙酰基-Β-D-吡喃半乳糖酰基-2,2,2-三氯代亚氨乙酸酯 在 三氟甲磺酸三甲基硅酯 作用下， 以 二氯甲烷 为溶剂， 反应 3.0h， 以64%的产率得到4-methoxyphenyl (2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-(1->3)-[(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-(1->4)]-2-O-acetyl-α-L-rhamnopyranoside
  参考文献：
  名称：

  Total synthesis of the heptasaccharide repeating unit of the iron-binding exopolysaccharide secreted by Klebsiella oxytoca BAS-10

  摘要：

  The first total synthesis of a heptasaccharide found in the iron-binding exopolysaccharide produced by Klebsiella oxytoca BAS-10 has been achieved in excellent yield using a block synthetic strategy. A trisaccharide glycosyl donor was stereoselectively coupled with a tetrasaccharide glycosyl acceptor using the trichloroacetimidate activation procedure. The yields and stereo outcome were excellent in each step of glycosylation. A late stage oxidation protocol was adopted for the oxidation of the primary hydroxyl group to the carboxylic functionality while keeping a secondary hydroxyl group unaffected. (c) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2009.07.009