4-[2-(3-nitrophenyl)-4,5-diphenylimidazole-1-yl]-benzenesulfonamide | 1172126-53-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-[2-(3-nitrophenyl)-4,5-diphenylimidazole-1-yl]-benzenesulfonamide
• 英文别名: 4-[2-(3-Nitrophenyl)-4,5-diphenylimidazol-1-yl]benzenesulfonamide
• CAS: 1172126-53-2
• 化学式: C₂₇H₂₀N₄O₄S
• 分子量: 496.546
• InChiKey: WJCDGBPOWLUYAU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  36
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  132
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  4-(3-Nitrobenzylideneamino)Benzenesulfonamide 、 联苯甲酰 在 ammonium acetate 作用下， 反应 0.35h， 以88%的产率得到4-[2-(3-nitrophenyl)-4,5-diphenylimidazole-1-yl]-benzenesulfonamide
  参考文献：
  名称：

  微波辅助，无溶剂的平行合成方法，阐明了一些具有生物学意义的新型四芳基咪唑的反应机理

  摘要：

  Abstract The microwave assisted, solvent free, parallel syntheses of title compounds is described in this protocol. Twelve new tetraaryl imidazoles, which are incorporated with the chemotherapeutic pharmacophores, have been synthesized by adopting one pot multicomponent reaction. Attempt has been made to investigate the mechanism behind the formation of tetraaryl imidazoles by product identification method. The synthesized compounds were analyzed by physical and analytical data. The synthesized compounds were evaluated for their antibacterial, antitubercular, and short‐term anticancer activity. Compound 13 was found to be the candidate compound to investigate further for its potential anticancer activity. J. Heterocyclic Chem., 46, 278 (2009).

  DOI：

  10.1002/jhet.68