2-bromo-4H,5H,6H-cyclopenta[b]thiophen-4-one | 1369353-77-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-bromo-4H,5H,6H-cyclopenta[b]thiophen-4-one
• 英文别名: 2-bromo-5,6-dihydrocyclopenta[b]thiophen-4-one
• CAS: 1369353-77-4
• 化学式: C₇H₅BrOS
• 分子量: 217.08
• InChiKey: YSGWNYYXJIIWDG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  45.3
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• HETEROCYCLIC PYRAZOLE DERIVATIVES AS TYPE III RECEPTOR TYROSINE KINASE INHIBITORS
  申请人：Development Center for Biotechnology

  公开号：EP4017853A1

  公开（公告）日：2022-06-29
• [EN] HETEROCYCLIC PYRAZOLE DERIVATIVES AS TYPE III RECEPTOR TYROSINE KINASE INHIBITORS<br/>[FR] DÉRIVÉS DE PYRAZOLE HÉTÉROCYCLIQUE EN TANT QU'INHIBITEURS DE TYROSINE KINASE DU RÉCEPTEUR DE TYPE III
  申请人：DEV CT BIOTECHNOLOGY

  公开号：WO2021041276A1

  公开（公告）日：2021-03-04

  A compound, which can act as inhibitors of protein kinases, especially Class III RTKs such as FLT3, PDGFRa, c-KIT and/or CSF-1R kinases, for the treatments of diseases or disorders mediated by such kinases, has a structure of formula (I): or a stereoisomer, a tautomer, a pharmaceutically acceptable salt, a binder of a Proteolysis-Targeting Chimera (PROTAC) thereof. The compound can be used in the treatments of diseases or conditions mediated by FLT3, PDGFR, c-KIT, and/or CSF-1R kinases, or mediated by a mutant kinase of FLT3, PDGFR, c-KIT, and/or CSF-1R kinases. Such diseases or conditions may include cancers, autoimmune diseases, and bone resorptive diseases.