O⁶-Lauroyl-D-galactose | 77607-15-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: O⁶-Lauroyl-D-galactose
• 英文别名: Glucose 6-monolaurate；[(2R,3R,4S,5R)-2,3,4,5-tetrahydroxy-6-oxohexyl] dodecanoate
• CAS: 77607-15-9
• 化学式: C₁₈H₃₄O₇
• 分子量: 362.464
• InChiKey: FTCGZXFZNUEELT-BURFUSLBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  25
• 可旋转键数：
  17
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  124
• 氢给体数：
  4
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  O¹,O²;O³,O⁴-diisopropylidene-O⁶-lauroyl-α-D-galactopyranose 在 盐酸 、 乙醚 作用下， 生成 O⁶-Lauroyl-D-galactose
  参考文献：
  名称：

  Hori, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1958, vol. 78, p. 1171

  摘要：

  DOI：

文献信息

• [EN] TRANS-ACIDOLYSIS PROCESS FOR THE PREPARATION OF SURFACE-ACTIVE CARBOHYDRATE FATTY-ACID ESTERS<br/>[FR] PROCEDE DE TRANS-ACIDOLYSE POUR PREPARER DES ESTERS D'ACIDE GRAS GLUCIDIQUES TENSIOACTIFS
  申请人：OBAJE OLOBO JONATHAN

  公开号：WO2004002997A1

  公开（公告）日：2004-01-08

  The present invention relates to a low temperature, solvent-free trans-acidolysis process for preparing surface-active carbohydrate fatty-acid esters comprising the steps of reacting acylated carbohydrate with free fatty acid in the presence of acid catalyst, under reduced pressure, and without adding any solvent; decolorizing and separating the reaction mixture thus obtained into unreacted fatty acid and carbohydrate fatty-esters by solvent extraction and stage cooling. Hydroxyl groups on the carbohydrate fatty-esters are selectively librated by partial hydrolysis in the presence of an acid catalyst to modify HLB of product fatty-esters. The unreacted free fatty acids and unreacted carbohydrate substrates removed during purification are recycled to the starting reactant mixture.

  本发明涉及一种低温、无溶剂的反酸化酯化过程，用于制备表面活性碳水化合物脂肪酸酯，包括以下步骤：在酸催化剂存在下，在减压条件下，无需添加任何溶剂，将酰化的碳水化合物与游离脂肪酸反应；将得到的反应混合物脱色并分离成未反应的脂肪酸和碳水化合物脂肪酯，通过溶剂萃取和分阶降温；在酸催化剂存在下，通过部分水解选择性地释放碳水化合物脂肪酯上的羟基，以改变产物脂肪酯的HLB值；在纯化过程中去除的未反应的游离脂肪酸和未反应的碳水化合物底物被回收到起始反应物混合物中。
• Trans-acidolysis process for the preparation of carbohydrate fatty-acid esters
  申请人：——

  公开号：US20020120133A1

  公开（公告）日：2002-08-29

  The present invention relates to a low temperature, solvent-free trans-acidolysis process for preparing surface-active carbohydrate fatty-acid esters comprising the steps of: (e) reacting acylated carbohydrate with free fatty acid in the presence of acid catalyst, under reduced pressure, and without adding any solvent; (f) decolorizing and separating the reaction mixture obtained in step (a) into unreacted fatty acid layer and a carbohydrate fatty-ester layer; (g) precipitating out the unreacted acylated carbohydrate; (h) librating the hydroxyl groups by partial hydrolysis in the presence of an acid catalyst; (i) removing the unreacted free fatty acids and unreacted carbohydrate esters of low molecular-weight carboxylic acids during purification, and recycling the removed unreacted free fatty acids and carbohydrate esters to the starting reactant mixture.

  本发明涉及一种用于制备表面活性碳水化合物脂肪酸酯的低温、无溶剂的反式酸解过程，包括以下步骤：(e)在酸催化剂的存在下，在减压条件下，无需添加任何溶剂，将酰化碳水化合物与游离脂肪酸反应；(f)将步骤(a)得到的反应混合物脱色并分离成未反应的脂肪酸层和碳水化合物脂肪酯层；(g)沉淀出未反应的酰化碳水化合物；(h)在酸催化剂的存在下，通过部分水解使羟基团解离；(i)在纯化过程中，去除未反应的游离脂肪酸和低分子量羧酸酯化碳水化合物酯，并将去除的未反应的游离脂肪酸和碳水化合物酯回收到起始反应物混合物中。
• METHODS AND COMPOSITIONS FOR TREATING EDEMA REFRACTORY TO ORAL DIURETICS
  申请人：RESQ Pharmaceuticals LLC

  公开号：US20210169833A1

  公开（公告）日：2021-06-10

  The present invention features methods and compositions for the intranasal, sublingual, and subcutaneous administration of bumetanide for the treatment of subjects suffering from edema refractory to oral diuretics.

  本发明涉及一种治疗口服利尿剂难以治疗的水肿患者的方法和组合物，其特点在于通过鼻内、舌下和皮下途径给予布美他尼德。
• Process for the selective preparation of derivatives of monosaccharides and polyols which are partially acylated
  申请人：Consejo Superior de Investigaciones Cientificas

  公开号：US06200784B1

  公开（公告）日：2001-03-13

  The process relates to the very selective enzymatic production of monosaccharides and polyols which are mono and/or bisubstituted with fatty acids. The process is based on the simple mixing of polyol or monosaccharide with the fatty acid, the addition of solvent, and the use of lipases in order to regioselectively obtain them without catalysts or toxic agents. The process requires continuous removal of water produced during the process. The invention applies to the sectors such as food, pharmaceutics, cosmetics and chemistry. The products obtained are excellent non ionic surfactant agents, which are biocompatible and biodegradable and are used as additives due to their emulgent, unctuous, thickening and hydrating characteristic.

  该过程涉及非常选择性的酶促单糖和聚醇的生产，这些单糖和聚醇是单或双脂肪酸取代的。该过程基于聚醇或单糖与脂肪酸的简单混合，加入溶剂，并使用脂肪酶以无需催化剂或有毒剂的方式进行区域选择性地制得它们。该过程需要不断去除过程中产生的水。该发明适用于食品、制药、化妆品和化学等领域。所获得的产品是优秀的非离子表面活性剂，具有生物相容性和生物降解性，并用作添加剂，因其乳化、润滑、增稠和保湿特性。
• NON-FLUORINATED URETHANE BASED COATINGS
  申请人：THE CHEMOURS COMPANY FC LLC

  公开号：US20160090508A1

  公开（公告）日：2016-03-31

  The present invention is an aqueous composition comprising at least one hydrophobic compound having at least one linkage of Formula I: —NHC(O)—X—  (I) wherein X is the residue of a cyclic or acyclic sugar alcohol which is substituted with at least one —R 1 ; —C(O)R 1 ; —(CH 2 CH 2 O) n (CH(CH 3 )CH 2 O) m R 2 ; —(CH 2 CH 2 O) n (CH(CH 3 )CH 2 O) m C(O)R 1 ; or mixtures thereof; where the cyclic or acyclic sugar alcohol is selected from a saccharide, reduced sugar, aminosaccharide, aldonic acid, or aldonic acid lactone; wherein each n is independently 0 to 20; each m is independently 0 to 20; m+n is greater than 0; each R 1 is independently a linear or branched alkyl group having 5 to 29 carbons optionally comprising at least 1 unsaturated bond; each R 2 is independently —H, a linear or branched alkyl group having 6 to 30 carbons optionally comprising at least 1 unsaturated bond, or mixtures thereof.

  本发明涉及一种水性组合物，其中至少包含一种具有至少一个式I连接的疏水化合物：—NHC（O）—X—（I），其中X是一个环状或非环状糖醇的残基，该糖醇被至少一个—R1；—C（O）R1；—（CH2 ）n（CH（CH3）CH2O）mR2；—（CH2 ）n（CH（ ） ）mC（O）R1；或其混合物所取代，所述环状或非环状糖醇从葡萄糖、还原糖、氨基葡萄糖、醛酸或醛酸内酯中选择；其中每个n独立地为0到20；每个m独立地为0到20；m+n大于0；每个R1独立地为具有5到29个碳原子的线性或支链烷基，可选地包含至少1个不饱和键；每个R2独立地为—H，具有6到30个碳原子的线性或支链烷基，可选地包含至少1个不饱和键，或其混合物。