(flavon-4'-yl)methanol | 700843-44-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: (flavon-4'-yl)methanol
• 英文别名: 2-[4-(Hydroxymethyl)phenyl]chromen-4-one
• CAS: 700843-44-3
• 化学式: C₁₆H₁₂O₃
• 分子量: 252.269
• InChiKey: MUIHMMNTKZGBQP-UHFFFAOYSA-N

物化性质

• 熔点：
  150-152 °C(Solv: ethanol (64-17-5))
• 沸点：
  440.0±45.0 °C(Predicted)
• 密度：
  1.306±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  丙二酸甲酯酰氯 、 (flavon-4'-yl)methanol 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 以89%的产率得到methyl 4'-flavonylmethyl malonate
  参考文献：
  名称：

  [60]Fullerene–flavonoid dyads

  摘要：

  A range of fullerene-chalcone, fullerene-flavone, and fullerene-chromone dyads, including a bis(flavonyl)-fullerene dyad, were prepared by 1,3-dipolar cycloaddition reactions of azomethine ylides to C-60 and by cyclopropanation of C-60 with flavonyl malonates. Synthetic and natural flavonoid derivatives were used as starting materials. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2004.03.003
• 作为产物：
  描述：

  4'-Flavone carboxaldehyde 在 sodium tetrahydroborate 作用下， 以 四氢呋喃 为溶剂， 反应 8.0h， 以80%的产率得到(flavon-4'-yl)methanol
  参考文献：
  名称：

  [60]Fullerene–flavonoid dyads

  摘要：

  A range of fullerene-chalcone, fullerene-flavone, and fullerene-chromone dyads, including a bis(flavonyl)-fullerene dyad, were prepared by 1,3-dipolar cycloaddition reactions of azomethine ylides to C-60 and by cyclopropanation of C-60 with flavonyl malonates. Synthetic and natural flavonoid derivatives were used as starting materials. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2004.03.003

文献信息

• Highly efficient synthesis of flavones via Pd/C-catalyzed cyclocarbonylation of 2-iodophenol with terminal acetylenes
  作者：Fengxiang Zhu、Yahui Li、Zechao Wang、Xiao-Feng Wu

  DOI：10.1039/c6cy00613b

  日期：——

  A highly efficient and selective Pd/C-catalyzed ligand-free cyclocarbonylation reaction for the synthesis of flavones has been developed. Various flavone derivatives were isolated in excellent yields with excellent functional group tolerances. Additionally, catalyst reuse experiments were performed successfully as well.

  已经开发出用于黄酮合成的高效且选择性的Pd / C催化的无配体环羰基化反应。以优异的产率和优异的官能团耐受性分离出各种黄酮衍生物。另外，催化剂再利用实验也成功进行。