2,4-dimethyl-pentane-2,3,4-triol | 79418-09-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2,4-dimethyl-pentane-2,3,4-triol
• 英文别名: α.α.α'.α'-Tetramethyl-glycerin；2,4-Dimethyl-pentan-2,3,4-triol；2,4-dimethyl-2,3,4-pentanetriol；2,4-Dimethylpentane-2,3,4-triol
• CAS: 79418-09-0
• 化学式: C₇H₁₆O₃
• 分子量: 148.202
• InChiKey: AIUFBIQURVCZNA-UHFFFAOYSA-N

物化性质

• 熔点：
  98-99 °C(Solv: hexane (110-54-3))
• 沸点：
  281.7±20.0 °C(Predicted)
• 密度：
  1.081±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  60.7
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2,4-dimethyl-pentane-2,3,4-triol 在 水 、 硼酸 作用下， 生成 4,4,6,6-tetramethyl-[1,3,2]dioxaborane-2,5-diol
  参考文献：
  名称：

  Pastureau; Veiler, Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1936, vol. 202, p. 1684

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 calcium hydroxide 作用下， 生成 2,4-dimethyl-pentane-2,3,4-triol
  参考文献：
  名称：

  Pastureau; Bernard, Bulletin de la Societe Chimique de France, 1923, vol. <4>33, p. 1450

  摘要：

  DOI：

文献信息

• PYRAZOLOPYRIMIDINE DERIVATIVE
  申请人：Mitsubishi Tanabe Pharma Corporation

  公开号：EP1903045A1

  公开（公告）日：2008-03-26

  A pyrazolopyrimidine derivative of the formula [I] wherein R1 is an optionally substituted aromatic ring group, an optionally substituted lower alkyl group or an optionally substituted amino group; R2 is an optionally substituted aromatic ring group; R3 is an optionally substituted lower alkyl group; and R4 is a hydrogen atom, a lower alkyl group, a halogen atom, a nitro group or an amino group; or a pharmaceutically acceptable salt thereof is useful as an antagonist of CRF receptor.

  公式[I]中的吡唑吡嘧啶衍生物，其中R1是可选择取代的芳香环基团、可选择取代的较低烷基基团或可选择取代的氨基团；R2是可选择取代的芳香环基团；R3是可选择取代的较低烷基基团；R4是氢原子、较低烷基基团、卤素原子、硝基基团或氨基团；或其药用可接受盐可用作CRF受体拮抗剂。
• Pyrazolopyrimidine Derivative
  申请人：Kashiwagi Toshihiko

  公开号：US20090234117A1

  公开（公告）日：2009-09-17

  A pyrazolopyrimidine derivative of the formula [I] wherein R 1 is an optionally substituted aromatic ring group, an optionally substituted lower alkyl group or an optionally substituted amino group; R 2 is an optionally substituted aromatic ring group; R 3 is an optionally substituted lower alkyl group; and R 4 is a hydrogen atom, a lower alkyl group, a halogen atom, a nitro group or an amino group; or a pharmaceutically acceptable salt thereof is useful as an antagonist of CRF receptor.

  公式[I]中的吡唑吡嗪衍生物，其中R1是可选取代的芳香环基团、可选取代的较低烷基团或可选取代的氨基团；R2是可选取代的芳香环基团；R3是可选取代的较低烷基团；R4是氢原子、较低烷基团、卤原子、硝基或氨基团；或其药学上可接受的盐，可用作CRF受体拮抗剂。
• External Preparation For The Skin
  申请人：Tominaga Naoki

  公开号：US20120183492A1

  公开（公告）日：2012-07-19

  An external preparation for skin has a pH value of 2.0-5.0 and comprises: (a) 1.0-7.0 mass % of at least one of the members selected from hydroxy acids, (b) 0-0.1-3.0 mass % of a crosslinked type N,N-dimethylacrylamide-2-acrylamido-2-methylpropane sulfonic acid sodium salt copolymer, and (c) 0-0.1-3.0 mass % of an associating thickener constituted of a compound of the formula (1): R 1 —(O—R 2 ) k —OCONH—R 3 [—NHCOO—(R 4 —O) n —R 5 ] h } m (1) wherein R 1 represents a hydrocarbon group, R 2 and R 4 represent alkylene groups having 2-4 carbon atoms, which may be identical or different, or a phenylethylene group, R 3 represents a hydrocarbon group, which may have a urethane bond, R 5 represents a branched chain or secondary hydrocarbon group, m is a number of at least 2, h is a number of at least 1, k is a number within the range of 1-500, and n is a number within the range of 1-200.

  一种外用皮肤制剂的pH值为2.0-5.0，包括：(a) 1.0-7.0质量％的至少一种羟基酸成员，(b) 0-0.1-3.0质量％的交联型N，N-二甲基丙烯酰胺-2-丙烯酰胺基-2-甲基丙烷磺酸钠共聚物，以及(c) 由式(1)的化合物构成的关联增稠剂，其质量％为0-0.1-3.0： R1—(O—R2)k—OCONH—R3[—NHCOO—(R4—O)n—R5]h}m(1) 其中，R1代表烃基，R2和R4代表具有2-4个碳原子的亚烷基基团，可以相同也可以不同，或苯乙烯基团，R3代表烃基，可以具有脲键，R5代表支链或次级烃基，m至少为2，h至少为1，k在1-500范围内，n在1-200范围内。
• METHOD FOR PRODUCING HOMOPOLYMER OR RANDOM COPOLYMER OF HYDROXYL GROUP-CONTAINING VINYL ETHER
  申请人：MARUZEN PETROCHEMICAL CO., LTD.

  公开号：US20150005467A1

  公开（公告）日：2015-01-01

  [Object] To provide a method of producing a homopolymer or random copolymer of hydroxyl group-containing vinyl ether simply and conveniently as well as efficiently. [Means for solving problem] A method of producing a homopolymer or random copolymer of hydroxyl group-containing vinyl ether according to the present invention comprises the step of polymerizing a monomer component comprising at least one hydroxyl group-containing vinyl ether using an oil-soluble radical polymerization initiator in the absence or presence of a solvent.

  【目标】提供一种简单、方便和高效的生产含羟基乙烯醚同聚物或随机共聚物的方法。 【解决问题的方法】根据本发明，生产含羟基乙烯醚同聚物或随机共聚物的方法包括以下步骤：使用油溶性自由基聚合引发剂，在有机溶剂存在或不存在的情况下，聚合至少含有一种羟基乙烯醚单体组分。
• Preparation of trifluoromethyl-substituted phenols and phenates and the preparation, from these phenols and phenates, of nitro- and trifluoromethyl-substituted diphenyl ethers
  申请人：ROHM AND HAAS COMPANY

  公开号：EP0019388A1

  公开（公告）日：1980-11-26

  Preparation of trifluoromethyl-substituted phenols and phenates and the preparation, from these phenols and phenates, of nitro- and tri-fluoromethyl-substituted diphenyl ethers. A novel process is provided for the preparation of a substituted phenate (or the corresponding phenol) of the formula: wherein X is halo or trifluoromethyl with the proviso that, when X is halo, X' is trifluoromethyl, X' is hydrogen, halo, trifluoromethyl or (C1-C4) alkyl, and M is the cation of an alkali metal or alkaline earth metal, wherein the process comprises reacting a compound of the formula (wherein X and X' are as above defined) with an alkali metal or alkaline earth metal hydroxide base in a solvent system which is substantially inertto said base and which comprises a polar, aprotic solvent with a dielectric constant in the range of from about 30 to about 70 and a non-nucleophilic hydroxy-containing solvent which increases the solubility of said base in the solvent system whereby a phenate is obtained and, if a phenol is the desired product, reacting the phenate with an acid to form the phenol. The phenates or phenols obtainable by the novel process may be used as intermediates in the preparation of trifluoromethylphenyl nitrophenylether herbicides optionally containing one or two additional ring substituents

  制备三氟甲基取代的苯酚和苯甲酸酯以及用这些苯酚和苯甲酸酯制备硝基和三氟甲基取代的二苯醚。 本发明提供了一种新工艺，用于制备式中的取代苯甲酸酯（或相应的苯酚）： 其中 X 为卤代或三氟甲基，但有以下条件 当 X 为卤素时，X'为三氟甲基、 X'是氢、卤素、三氟甲基或（C1-C4）烷基，以及 M 是碱金属或碱土金属的阳离子、 其中，该工艺包括使以下式子的化合物发生反应 (其中 X 和 X'如上定义）与碱金属或碱土金属氢氧化物碱在溶剂体系中反应，该溶剂体系对所述碱基本上是惰性的，它包括介电常数在约 30 至约 70 范围内的极性烷基溶剂和可增加所述碱在溶剂体系中溶解度的非亲核含羟基溶剂，从而得到苯酸盐，如果苯酚是所需产物，则使苯酸盐与酸反应生成苯酚。 通过新工艺得到的苯酸盐或苯酚可用作中间体，用于制备三氟甲基苯基硝基苯基醚除草剂，该除草剂可选择含有一个或两个额外的环取代基。