(4E)-3-methyl-N-pyridin-3-yl-4-[3-(pyridin-2-yloxy)benzylidene]piperidine-1-carboxamide | 1191288-07-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (4E)-3-methyl-N-pyridin-3-yl-4-[3-(pyridin-2-yloxy)benzylidene]piperidine-1-carboxamide
• 英文别名: (4E)-3-methyl-N-pyridin-3-yl-4-[(3-pyridin-2-yloxyphenyl)methylidene]piperidine-1-carboxamide
• CAS: 1191288-07-9
• 化学式: C₂₄H₂₄N₄O₂
• 分子量: 400.48
• InChiKey: DMCWQHFYVODUSD-XSFVSMFZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  30
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  67.4
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• 4- [3- (ARYLOXY) BENZYLIDENE]-3-METHYL PIPERIDINE ARYL CARBOXAMIDE COMPOUNDS USEFUL AS FAAH INHIBITORS
  申请人：Pfizer Inc.

  公开号：EP2276737A1

  公开（公告）日：2011-01-26
• [EN] 4- [3- (ARYLOXY) BENZYLIDENE] -3-METHYL PIPERIDINE ARYL CARBOXAMIDE COMPOUNDS USEFUL AS FAAH INHIBITORS<br/>[FR] COMPOSÉS ARYL CARBOXAMIDES DE 4-[3-(ARYLOXY)BENZYLIDÈNE]-3-MÉTHYL PIPÉRIDINE UTILES COMME INHIBITEURS DE LA FAAH
  申请人：PFIZER

  公开号：WO2009127949A1

  公开（公告）日：2009-10-22

  The present invention relates to compounds of Formula (I), wherein Ar is optionally substituted phenyl or heteroaryl and X, Y and Z are independently N or CH; or a pharmaceutically acceptable salt thereof; processes for the preparation of the compounds; intermediates used in the preparation of the compounds; compositions containing the compounds; and uses of the compounds in treating diseases or conditions associated with fatty acid amide hydrolase (FAAH) activity.