4-甲基-2-氧代戊酸钙 | 51828-95-6

• 物质功能分类: 医药中间体
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 酮酸及其衍生物
• 中文名称: 4-甲基-2-氧代戊酸钙
• 中文别名: 4-甲基-2-戊酮酸钙；alpha-酮基亮氨酸钙盐；2-酮亮氨酸钙；Α酮异己酸钙；氧代异己酸钙；2-羰基异己酸；4-甲基-2-氧戊酸钙；a-异己酮酸钙；α-酮异己酸钙；4-甲基-2-酮基戊酸钙
• 英文名称: 2-Ketoleucine calcium salt
• CAS: 51828-95-6
• 化学式: C6H10CaO3
• 分子量: 170.22
• InChiKey: YJAKVPKJJMFDNW-UHFFFAOYSA-N

物化性质

• 熔点：
  >300°C
• 溶解度：
  可溶于DMSO（轻微），水（非常轻微，超声处理）
• 稳定性/保质期：

  如果按照规格使用和储存，则不会分解，也未有已知危险反应。

计算性质

• 辛醇/水分配系数(LogP)：
  0.31
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 安全说明：
  S22,S24/25

制备方法与用途

用途：用于农药和医药中间体、运动营养成分以及营养补充剂。

文献信息

• Supplemental dietary composition for enhancing muscle performance and/or recovery from fatigue
  申请人：Gakic Formulations Ltd.

  公开号：EP1754415A1

  公开（公告）日：2007-02-21

  A supplemental dietary composition which, e.g., enhances muscle performance or recovery from fatigue, including glycine and L-arginine alpha-ketoisocaproic acid calcium (GAKIC), wherein the L-arginine is in a base or monohydrochloride salt form, and an effective amount of a flavor component, e.g., a bitter-mask flavor, acesulfame potassium (ACE-K), etc. The GAKIC may be in granular or fine milled form. Also provided is a method of enhancing muscle performance or recovery from fatigue by consuming a supplemental dietary compositions that includes GAKIC and an effective amount of a flavor component. Also provided is a method for preparing compositions including GAKIC and an effective amount of a flavor component.

  一种补充性膳食组合物，例如可提高肌肉表现或从疲劳中恢复，包括甘氨酸和 L-精氨酸α-酮异癸酸钙（GAKIC），其中 L-精氨酸为碱式或单盐酸盐形式，以及有效量的风味成分，例如苦味面膜风味、安赛蜜钾（ACE-K）等。GAKIC 可以是颗粒状或细磨状。还提供了一种通过摄入补充性膳食组合物提高肌肉性能或恢复疲劳的方法，该组合物包括 GAKIC 和有效量的香料成分。还提供了一种制备包括GAKIC和有效量香料成分的组合物的方法。
• Supplemental dietary composition for turning on anabolic switches in muscle, stimulating and/or optimizing protein synthesis, and/or potently signaling muscle building and/or growth via molecular pathways
  申请人：Heuer A. Marvin

  公开号：US20070105942A1

  公开（公告）日：2007-05-10

  Compositions and methods relating to the use of cationic and monobasic amino acids combined with ketoacids for the purposes of regulating molecular signals to control anabolic and anti-catabolic activity in skeletal muscular development are disclosed. The present invention is designed to influence the genetic control system for muscle protein synthesis to stimulate muscle growth, increase muscle mass, decrease muscle catabolism, decrease recovery time and to treat muscle wasting and/or degeneration. Said compositions are to be administered to a subject one to four times daily.
• Kit comprising three independent compositions and methods for building muscle, increasing strength, increasing muscle size, increasing muscle performance and reducing muscle fatigue
  申请人：Gardiner T. Paul

  公开号：US20070117867A1

  公开（公告）日：2007-05-24

  A kit, and a method of using same, that comprises first, second and third components wherein the first, second and third components collectively comprise Glycine, Arginine, Leucine, Creatine, Alpha Lipoic Acid, and earth metal salts of Ketoisocaproic Acid. Use of the kit may enhance muscle performance, build muscle, increase muscle strength, increase muscle size and reduce muscle fatigue. The three compositions may be used in synergy so as to promote muscle anabolism, neutralize reactive oxygen species, and improve creatine uptake in muscle tissue. The method may also include a schedule for administering each composition to the user for optimal results.
• Pathway Analysis of Cell Culture Phenotypes and Uses Thereof
  申请人：Melville Mark

  公开号：US20090186358A1

  公开（公告）日：2009-07-23

  The present invention provides methods for systematically identifying genes, proteins and/or related pathways that regulate or indicative of cell phenotypes. The present invention further provides methods for manipulating the identified genes, proteins and/or pathways to engineer improved cell lines and/or to evaluate or select cell lines with desirable phenotypes.
• USE OF JASMONATE FOR IMPROVING SKELETAL MUSCLE FUNCTION
  申请人：Broady Brunde

  公开号：US20120172450A1

  公开（公告）日：2012-07-05

  A formulation comprising jasmonate for improving skeletal muscle function in a mammal, particularly a human is provided. This may be accomplished by reducing muscle fatigue and/or increasing skeletal muscle performance.