(5-chloro-benzofuran-2-yl)-[4-(4-chloro-benzoyl)-piperidin-1-yl]-methanone | 894795-35-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (5-chloro-benzofuran-2-yl)-[4-(4-chloro-benzoyl)-piperidin-1-yl]-methanone
• 英文别名: [1-(5-Chloro-1-benzofuran-2-carbonyl)piperidin-4-yl]-(4-chlorophenyl)methanone
• CAS: 894795-35-8
• 化学式: C₂₁H₁₇Cl₂NO₃
• 分子量: 402.277
• InChiKey: PFSLTZSGVLFZQE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  27
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  50.5
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• COMPOUNDS WITH KV4 ION CHANNEL ACTIVITY
  申请人：Devgen N.V.

  公开号：EP1838690A2

  公开（公告）日：2007-10-03
• Compounds With Kv4 Ion Channel Activity
  申请人：Blom Petra

  公开号：US20080039442A1

  公开（公告）日：2008-02-14

  The present invention relates to compounds that interact with ion channels. In particular, the invention relates to compounds having the structural Formula (I), (II), (III) or (IV), stereoisomers, tautomers, racemics, prodrugs, metabolites thereof, or a pharmaceutically acceptable salt and/or solvate thereof, Formula (I), (II), (III), (IV), wherein X 1 , X 2 , Y, Z, W, R 1 , R 8 , R 9 , R 10 , L, A, z, and n have the meaning defined in claim 1 . The invention also relates to methods for preparing said compounds, to pharmaceutical compositions comprising said compounds, and to the use of said compounds in methods for treatment of the human and animal body.
• [EN] COMPOUNDS THAT INTERACT WITH ION CHANNELS, IN PARTICULAR WITH ION CHANNELS FROM THE KV FAMILY<br/>[FR] COMPOSES INTER-REAGISSANT AVEC DES CANAUX IONIQUES, EN PARTICULIER AVEC DES CANAUX IONIQUES DE LA FAMILLE KV
  申请人：DEVGEN NV

  公开号：WO2006066879A2

  公开（公告）日：2006-06-29

  [EN] The present invention relates to compounds that interact with ion channels. In particular, the invention relates to compounds having the structural Formula (I), (II), (III) or (IV), stereoisomers, tautomers, racemics, prodrugs, metabolites thereof, or a pharmaceutically acceptable salt and/or solvate thereof, Formula (I), (II), (III), (IV), wherein X¹, X², Y, Z, W, R¹, R⁸ , R⁹, R¹⁰, L, A, z, and n have the meaning defined in claim 1. The invention also relates to methods for preparing said compounds, to pharmaceutical compositions comprising said compounds, and to the use of said compounds in methods for treatment of the human and animal body.
  [FR] L'invention concerne des composés inter-réagissant avec des canaux ioniques. En particulier, l'invention concerne des composés ayant la formule développée (I), (II), (III) ou (IV), des stéréoisomères, des tautomères, des racémiques, des promédicaments, des métabolites de ces composés, ou un sel et/ou un solvat pharmaceutiquement acceptable desdits composés, formules dans lesquelles X¹, X², Y, Z, W, R¹, R⁸, R⁹, R¹⁰, L, A, z, et n ont les significations spécifiées dans la revendication 1. L'invention concerne également des procédés de préparation desdits composés, des compositions pharmaceutiques comprenant lesdits composés et l'utilisation de ces composés dans des procédés de traitement du corps humain ou animal.