diethyl 3,3-dimethyl-(+/-)-trans-1,2-cyclopropandioate | 67776-64-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: diethyl 3,3-dimethyl-(+/-)-trans-1,2-cyclopropandioate
• 英文别名: diethyl (±)-(1R,2R)-3,3-dimethylcyclopropane-1,2-dicarboxylate；trans-diethyl 3,3-dimethylcyclopropane-1,2-dicarboxylate；(+/-)-3.3-dimethyl-cyclopropane-dicarboxylic acid-(1r.2t)-diethyl ester；(+/-)-3.3-Dimethyl-cyclopropan-dicarbonsaeure-(1r.2t)-diaethylester；trans-Diethyl caronate；diethyl (1R,2R)-3,3-dimethylcyclopropane-1,2-dicarboxylate
• CAS: 67776-64-1
• 化学式: C₁₁H₁₈O₄
• 分子量: 214.262
• InChiKey: MPRMNWDIYNBXRC-YUMQZZPRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  diethyl 3,3-dimethyl-(+/-)-trans-1,2-cyclopropandioate 在 manganese(IV) oxide 、 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 、 氯仿 为溶剂， 反应 37.0h， 生成 (1R,2R)-3,3-dimethylcyclopropane-1,2-dicarbaldehyde
  参考文献：
  名称：

  宝石-二甲基取代的二乙烯基环丙烷 的应对重排†

  摘要：

  已经研究了一定范围的取代的二乙烯基环丙烷对热Cope重排的反应性。考察了宝石-二甲基取代对环丙烷的影响，烯烃的几何形状，环丙烷的相对立体化学以及一系列官能团的空间和电子效应，并将开发的方法用于合成一系列官能化的1 ，4-环庚二烯的高收率。

  DOI：

  10.1039/c3ob41617h
• 作为产物：
  描述：

  富马酸二乙酯 在 triisopropylsulfoxonium tetrafluoroborate 、 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 、 mineral oil 为溶剂， 反应 2.0h， 以73%的产率得到diethyl 3,3-dimethyl-(+/-)-trans-1,2-cyclopropandioate
  参考文献：
  名称：

  宝石-二甲基取代的二乙烯基环丙烷 的应对重排†

  摘要：

  已经研究了一定范围的取代的二乙烯基环丙烷对热Cope重排的反应性。考察了宝石-二甲基取代对环丙烷的影响，烯烃的几何形状，环丙烷的相对立体化学以及一系列官能团的空间和电子效应，并将开发的方法用于合成一系列官能化的1 ，4-环庚二烯的高收率。

  DOI：

  10.1039/c3ob41617h

文献信息

• US2014/275029
  申请人：——

  公开号：——

  公开（公告）日：——
• Enzymes in organic synthesis. 24. Preparations of enantiomerically pure chiral lactones via stereospecific horse liver alcohol dehydrogenase catalyzed oxidations of monocyclic meso diols
  作者：Ignac J. Jakovac、H. Bruce Goodbrand、Kar P. Lok、J. Bryan Jones

  DOI：10.1021/ja00381a024

  日期：1982.8
• A Demonstration of Postpellet Application of Dry Phytase to Broiler Diets
  作者：F.W. Edens、C.R. Parkhurst、P.R. Ferket、G.B. Havenstein、A.E. Sefton

  DOI：10.1093/japr/11.1.34

  日期：2002.3

  A comparison of performance and P reduction in litter and manure from broilers fed rations with and without phytase enzyme was made with chickens reared on litter or in cages. Low-activity phytase supplemented as a dry powder to mash diets did not affect performance, but litter P accumulation was decreased 14 to 21% during the starter and grower phases. Liquid phytase applied postpelleting to diets with 0.5% total P (0.3% available P) reduced litter P accumulation (14 to 19%) and reduced manure P content in starter, grower, and finisher phases of the study. Phosphorus content in raw manure was decreased by 55% during the finisher phase. Feed conversions of broliers in cages and on conventional litter-covered floors were improved significantly with postpellet application of liquid phytase. Feed conversion improvement was greater in birds in cages. Postpellet application of dry phytase was shown to be feasible based upon performance and reduction in litter P accumulation. Feed conversions were improved by 7 to 8 points (P < 0.05) when compared to those of birds given a normal P level (0.72% total P) diet without phytase. Litter P accumulation was reduced between 20.5 and 28.5% with dry phytase applied postpelleting. With liquid phytase applied postpelleting, litter P accumulation was reduced 26.6% These reductions in litter P content represent about 4 lb of P per ton of litter.