3-(2-dimethylaminoethoxy)thiophene | 864229-54-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-(2-dimethylaminoethoxy)thiophene
• 英文别名: N,N-Dimethyl-2-(3-thienyloxy)ethanamine；N,N-dimethyl-2-thiophen-3-yloxyethanamine
• CAS: 864229-54-9
• 化学式: C₈H₁₃NOS
• 分子量: 171.263
• InChiKey: LTIHFTFNBYZDRD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  40.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-溴噻吩 、 N,N-二甲基乙醇胺 在 copper(l) iodide 、 铜 potassium phosphate 作用下， 生成 3-(2-dimethylaminoethoxy)thiophene
  参考文献：
  名称：

  A mild and practical copper catalyzed amination of halothiophenes

  摘要：

  We have found that N,N-dimethylethanolamine (deanol) is a useful solvent and ligand for copper catalyzed amination of a variety of unactivated and activated 2- or 3-halothiophenes. Primary amines, acyclic secondary amines, cyclic secondary amines and acyclic secondary amines with 2-hydroxyethyl functionality react with halothiophenes in moderate to excellent yields. The mildly basic conditions utilized are compatible with many functional groups. The animation of halobithiophenes has also been examined. The aminothiophenes produced by this method are important intermediates in a variety of electronic and optoelectronic materials. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2004.11.017