N-[3-methoxy-4-(2-methyl-5-oxazolyl)phenyl]-2-(3-methoxyphenyl)-3-methyl-2H-pyrazolo[3,4-c]pyridin-7-amine | 1259032-65-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N-[3-methoxy-4-(2-methyl-5-oxazolyl)phenyl]-2-(3-methoxyphenyl)-3-methyl-2H-pyrazolo[3,4-c]pyridin-7-amine
• 英文别名: N-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-2-(3-methoxyphenyl)-3-methylpyrazolo[3,4-c]pyridin-7-amine
• CAS: 1259032-65-9
• 化学式: C₂₅H₂₃N₅O₃
• 分子量: 441.489
• InChiKey: XBRRNLYAGOBTMV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  33
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  87.2
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• SUBSTITUTED INDAZOLE AND AZA-INDAZOLE DERIVATIVES AS GAMMA SECRETASE MODULATORS
  申请人：Janssen Pharmaceuticals, Inc.

  公开号：EP2427453B1

  公开（公告）日：2013-07-17
• NOVEL SUBSTITUTED INDAZOLE AND AZA-INDAZOLE DERIVATIVES AS GAMMA SECRETASE MODULATORS
  申请人：Bischoff François Paul

  公开号：US20120095036A1

  公开（公告）日：2012-04-19

  The present invention is concerned with novel substituted indazole and aza-indazole derivatives of Formula (I) wherein R 1 , R 2 , R 3 , R 4 , Y, A 1 , A 2 , A 3 , A 4 , X 1 , X 2 , X 3 and Het 1 have the meaning defined in the claims. The compounds according to the present invention are useful as gamma secretase modulators. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
• US8835482B2
  申请人：——

  公开号：US8835482B2

  公开（公告）日：2014-09-16