3-(4,5-dihydro-pyrrolo[3,2,1-hi]indol-1-yl)-4-(1H-indol-3-yl)-pyrrole-2,5-dione | 345265-40-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 3-(4,5-dihydro-pyrrolo[3,2,1-hi]indol-1-yl)-4-(1H-indol-3-yl)-pyrrole-2,5-dione
• 英文别名: 3-(4-azatricyclo[5.3.1.04,11]undeca-1(10),2,7(11),8-tetraen-2-yl)-4-(1H-indol-3-yl)pyrrole-2,5-dione
• CAS: 345265-40-9
• 化学式: C₂₂H₁₅N₃O₂
• 分子量: 353.38
• InChiKey: MEKTXYRSIBNNSZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  27
• 可旋转键数：
  2
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  66.9
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-(4,5-dihydro-pyrrolo[3,2,1-hi]indol-1-yl)-4-(1H-indol-3-yl)-pyrrole-2,5-dione 在 甲醇 、 magnesium 作用下， 反应 1.5h， 生成 (+/-)-trans-3-(4,5-dihydro-pyrrolo[3,2,1-hi]indol-1-yl)-4-(1H-indol-3-yl)-pyrrolidine-2,5-dione
  参考文献：
  名称：

  WO2009/2807

  摘要：

  公开号：
• 作为产物：
  描述：

  (4,5-dihydro-pyrrolo[3,2,1-hi]indol-1-yl)-oxo-acetic acid methyl ester 在 盐酸 、 potassium tert-butylate 作用下， 以 四氢呋喃 为溶剂， 生成 3-(4,5-dihydro-pyrrolo[3,2,1-hi]indol-1-yl)-4-(1H-indol-3-yl)-pyrrole-2,5-dione
  参考文献：
  名称：

  1,7-Annulated indolocarbazoles as cyclin-dependent kinase inhibitors

  摘要：

  The synthesis and kinase inhibitory activity of a series of novel 1,7-annulated indolocarbazoles 6 and 16 is described. These compounds exhibited potent inhibitory activity against cyclin-dependent kinase 4 and good antiproliferative activity in a human colon carcinoma cell line. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.03.105

文献信息

• Compositions and Methods for the Treatment of Cancer
  申请人：Westlund Neil

  公开号：US20100183603A1

  公开（公告）日：2010-07-22

  The present invention relates to pyrrolidine-2,5-dione compounds, and methods of preparation of these compounds. The present invention also relates to pharmaceutical compositions comprising pyrrolidine-2,5-dione compounds. The present invention provides methods of treating a cell proliferative disorder, such as a cancer, by administering to a subject in need thereof a therapeutically effective amount of a compound or pyrrolidine-2,5-dione compound of the present invention. (Ia) (Ib) (IIa) (IIIb) Where U is independently selected from: (I) or (II) where U is independently selected from:

  本发明涉及吡咯烷-2,5-二酮化合物及其制备方法。本发明还涉及包含吡咯烷-2,5-二酮化合物的制药组合物。本发明提供了通过向需要治疗细胞增殖性疾病，如癌症的患者施用本发明化合物或吡咯烷-2,5-二酮化合物的治疗有效剂量来治疗该疾病的方法。(Ia) (Ib) (IIa) (IIIb)其中U独立地选自：(I)或(II)，其中U独立地选自：
• Compositions and methods for the treatment of cancer
  申请人：Westlund Neil

  公开号：US08513292B2

  公开（公告）日：2013-08-20

  The present invention relates to pyrrolidine-2,5-dione compounds, and methods of preparation of these compounds. The present invention also relates to pharmaceutical compositions comprising pyrrolidine-2,5-dione compounds. The present invention provides methods of treating a cell proliferative disorder, such as a cancer, by administering to a subject in need thereof a therapeutically effective amount of a compound or pyrrolidine-2,5-dione compound of the present invention. (Ia) (Ib) (IIa) (IIIb) Where U is independently selected from: (I) or (II) where U is independently selected from:

  本发明涉及吡咯烷-2,5-二酮化合物及其制备方法。本发明还涉及包括吡咯烷-2,5-二酮化合物的药物组合物。本发明提供了通过向需要治疗细胞增殖性疾病（如癌症）的患者施用本发明化合物或吡咯烷-2,5-二酮化合物的治疗有效剂量来治疗的方法。（Ia）（Ib）（IIa）（IIIb）其中U是独立选择自：（I）或（II）其中U是独立选择自：
• Indolyl pyrrolidines for the treatment of cancer
  申请人：ArQule, Inc.

  公开号：EP2392574A1

  公开（公告）日：2011-12-07

  The present invention relates to pyrrolidine-2,5-dione compounds, and methods of preparation of these compounds. The present invention also relates to pharmaceutical compositions comprising pyrrolidine-2,5-dione compounds. The present invention provides methods of treating a cell proliferative disorder, such as a cancer, by administering to a subject in need thereof a therapeutically effective amount of a compound or pyrrolidine-2,5-dione compound of the present invention. where U is:

  本发明涉及吡咯烷-2,5-二酮化合物及其制备方法。本发明还涉及包含吡咯烷-2,5-二酮化合物的药物组合物。本发明提供了治疗细胞增殖性疾病（如癌症）的方法，其方法是向有需要的受试者施用治疗有效量的本发明化合物或吡咯烷-2,5-二酮化合物。 其中U是
• INDOLYL PYRROLIDINES FOR THE TREATMENT OF CANCER
  申请人：ArQule, Inc.

  公开号：EP2173748A2

  公开（公告）日：2010-04-14
• US8513292B2
  申请人：——

  公开号：US8513292B2

  公开（公告）日：2013-08-20