4-Brom-3-methyl-butanol-(1) | 89211-44-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-Brom-3-methyl-butanol-(1)
• 英文别名: 4-bromo-3-methyl-butan-1-ol；4-bromo-3-methylbutanol；4-Bromo-3-methylbutan-1-ol
• CAS: 89211-44-9
• 化学式: C₅H₁₁BrO
• 分子量: 167.046
• InChiKey: XJENZFJXAHFAQI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  7
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4-Brom-3-methyl-butanol-(1) 在 氢氧化钾 、 copper(l) iodide 、 四氯化钛 、 magnesium 、 三乙胺 、 锌 作用下， 以 二氯甲烷 为溶剂， 反应 30.5h， 生成
  参考文献：
  名称：

  Enantioselective total synthesis of (+)-labd-8(17)-ene-3β,15-diol and (−)-labd-8(17)-ene-3β,7α,15-triol

  摘要：

  Enantioselective total synthesis of the labdane diterpenes (+)-labd-8(17)-ene-3 beta,15-diol ((+)-1) and (-)-labd-8(17)-ene-3 beta,7 alpha, 15-triol ((-)-2) was achieved starting from the (S)-(+)-enantiomer of the Wieland-Miescher ketone (+)-3 and the (R)-(+)-enantiomer of lactone (+)-13. These results established that the natural compounds (+)-1 and (-)-2 possess the (13S) absolute configuration. (C) 1997 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(97)00346-8
• 作为产物：
  描述：

  4-溴-3-甲基丁酸甲酯 在 lithium aluminium tetrahydride 作用下， 生成 4-Brom-3-methyl-butanol-(1)
  参考文献：
  名称：

  Ioffe,D.V.; Kuznetsov,S.G., Journal of general chemistry of the USSR, 1962, vol. 32, p. 3183 - 3188

  摘要：

  DOI：

文献信息

• Polyprenyl composition or compounds and process for the production
  申请人：Kuraray Co., Ltd.

  公开号：US04886904A1

  公开（公告）日：1989-12-12

  A polyprenyl composition consisting essentially of a mixture of polyprenyl compounds represented by the following formula ##STR1## wherein A.sub.1 represents a hydroxyl or acetyloxy group, ##STR2## represents a trans-isoprene unit, ##STR3## represents a cis-isoprene unit, and n is an integer of from 11 to 19, said mixture containing substantial amounts of at least three compounds of formula (I) wherein n represents 14, 15 and 16 respectively as essential ingredients in a total amount of at least 70% by weight based on the weight of the mixture; and new compounds derived from the polyprenyl compounds of formula (I). These composition and compounds are useful for the synthesis of mammalian dolichols. The polyprenyl composition can be prepared by extracting the leaves of Ginkgo biloba or Cedrus deodara with an oil-soluble organic solvent; if required, hydrolyzing the extract; and subjecting the extract to one or more of chromatography, fractional dissolution, fractional refrigerating precipitation and molecular distillation, thereby separating and recovering a fraction having a specified Rf value in silica thin-layer chromatography.

  一种多萜化合物组成物，基本上由以下式子所代表的多萜化合物混合物组成：##STR1## 其中A.sub.1代表羟基或乙酰氧基，##STR2##代表反式异戊二烯基，##STR3##代表顺式异戊二烯基，n为11至19之间的整数，该混合物包含式(I)中n分别代表14、15和16的至少三种化合物，作为至少70%的重量百分比的必要成分，基于混合物的重量；以及由式(I)多萜化合物衍生的新化合物。这些组成物和化合物可用于合成哺乳动物的长链醇。多萜化合物组成物可以通过使用油溶性有机溶剂提取银杏或雪松的叶子来制备；必要时，水解提取物；并将提取物经过色谱、分级溶解、分级冷沉淀和分子蒸馏中的一个或多个步骤，从而分离和回收具有硅胶薄层色谱中指定Rf值的分数。
• Polyprenyl composition of compounds and process for the production
  申请人：Kuraray Co., Ltd.

  公开号：US05012018A1

  公开（公告）日：1991-04-30

  A polyprenyl composition consisting essentially of a mixture of polyprenyl compounds represented by the following formula ##STR1## wherein A.sub.1 represents a hydroxyl or acetyloxy group, ##STR2## represents a trans-isoprene unit ##STR3## represents a cis-isoprene unit, and n is an integer of from 11 to 19, said mixture containing substantial amounts of at least three compounds of formula (I) wherein n represents 14, 15 and 16 respectively as essential ingredients in a total amount of at least 70% by weight based on the weight of the mixture; and new compounds derived from the polyprenyl compounds of formula (I). These composition and compounds are useful for the synthesis of mammalian dolichols. The polyprenyl composition can be prepared by extracting the leaves of Ginkgo biloba or Cedrus deodara with an oil-soluble organic solvent; if required, hydrolyzing the extract; and subjecting the extract to one or more of chromatography, fractional dissolution, fractional refrigerating precipitation and molecular distillation, thereby separating and recovering a fraction having a specified Rf value in silica thin-layer chromatography.

  一种聚戊二烯组合物，基本上由以下式表示的聚戊二烯化合物混合物组成：其中A.sub.1代表羟基或乙酰氧基，代表反式异戊二烯单元，代表顺式异戊二烯单元，n为11至19的整数，所述混合物含有至少三种分别表示为n分别为14、15和16的式(I)化合物的重要成分，其总量至少占混合物重量的70％；以及从式(I)聚戊二烯化合物衍生的新化合物。这些组合物和化合物可用于合成哺乳动物多立醇。聚戊二烯组合物可以通过用油溶性有机溶剂提取银杏叶或雪松叶制备；如有必要，水解提取物；并将提取物经过色谱、分级溶解、分级冷却沉淀和分子蒸馏中的一种或多种处理，从而分离和回收在硅胶薄层色谱中具有指定Rf值的分数。
• Ioffe,D.V.; Kuznetsov,S.G., Journal of general chemistry of the USSR, 1962, vol. 32, p. 3183 - 3188
  作者：Ioffe,D.V.、Kuznetsov,S.G.

  DOI：——

  日期：——
• Enantioselective total synthesis of (+)-labd-8(17)-ene-3β,15-diol and (−)-labd-8(17)-ene-3β,7α,15-triol
  作者：Alexander Pemp、Karlheinz Seifert

  DOI：10.1016/s0040-4039(97)00346-8

  日期：1997.3

  Enantioselective total synthesis of the labdane diterpenes (+)-labd-8(17)-ene-3 beta,15-diol ((+)-1) and (-)-labd-8(17)-ene-3 beta,7 alpha, 15-triol ((-)-2) was achieved starting from the (S)-(+)-enantiomer of the Wieland-Miescher ketone (+)-3 and the (R)-(+)-enantiomer of lactone (+)-13. These results established that the natural compounds (+)-1 and (-)-2 possess the (13S) absolute configuration. (C) 1997 Published by Elsevier Science Ltd.