(2R,3R,4S,5R)-5-azido-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-isobutyryloxy-5-isobutyryloxymethyltetrahydrofuran-3-yl isobutyrate | 1312330-63-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2R,3R,4S,5R)-5-azido-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-isobutyryloxy-5-isobutyryloxymethyltetrahydrofuran-3-yl isobutyrate
• 英文别名: isobutyric acid (2R,3R,4S,5R)-5-azido-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-isobutyryloxy-5-isobutyryloxymethyl-tetrahydro-furan-3-yl ester；[(2R,3S,4R,5R)-2-azido-5-(2,4-dioxopyrimidin-1-yl)-3,4-bis(2-methylpropanoyloxy)oxolan-2-yl]methyl 2-methylpropanoate
• CAS: 1312330-63-4
• 化学式: C₂₁H₂₉N₅O₉
• 分子量: 495.489
• InChiKey: NYJVJQKOCDXWCX-DXEZIKHYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  35
• 可旋转键数：
  12
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  152
• 氢给体数：
  1
• 氢受体数：
  11

文献信息

• ANTIVIRAL NUCLEOSIDES
  申请人：Ma Han

  公开号：US20110150829A1

  公开（公告）日：2011-06-23

  Compounds having the formula I wherein R 1 , R 2 and R 3 are as defined herein are Hepatitis C virus NS5 b polymerase inhibitors. Also disclosed are compositions and methods for treating an HCV infection and inhibiting HCV replication.

  具有I式的化合物，其中R1、R2和R3如此定义，是丙型肝炎病毒NS5b聚合酶抑制剂。还揭示了治疗HCV感染和抑制HCV复制的组合物和方法。
• [EN] 4 ' - AZIDO - NUCLEOSIDES AS ANTI - HCV COMPUNDS<br/>[FR] 4'-AZIDO-NUCLÉOSIDES UTILISÉS EN TANT QUE COMPOSÉS ANTI-VHC
  申请人：HOFFMANN LA ROCHE

  公开号：WO2011092158A1

  公开（公告）日：2011-08-04

  Compounds having the formula I wherein R1, R2 and R3 are as defined herein are Hepatitis C virus NS5b polymerase inhibitors. Also disclosed are compositions and methods for treating an HCV infection and inhibiting HCV replication.