4-甲基-吗啉-2-羧酸盐酸盐 | 841274-05-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 中文名称: 4-甲基-吗啉-2-羧酸盐酸盐
• 中文别名: 2-羧基-4-甲基吗啉盐酸盐
• 英文名称: 4-Methylmorpholine-2-carboxylic acid hydrochloride
• 英文别名: 4-methylmorpholine-2-carboxylic acid;hydrochloride
• CAS: 841274-05-3
• 化学式: C6H12ClNO3
• mdl: MFCD06738959
• 分子量: 181.62
• InChiKey: HWHCYNGGRABGQT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.03
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.833
• 拓扑面积：
  49.8
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• 海关编码：
  2934999090

反应信息

• 作为反应物：
  描述：

  4-甲基-吗啉-2-羧酸盐酸盐 、 O-(7-azabenzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate 、 N,N-二异丙基乙胺 、 6-(1H-indol-4-yl)-1H-indazol-4-amine 在 氯仿 、 甲醇乙酸乙酯 、 氮 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 20.08h， 生成 N-[6-(1H-indol-4-yl)-1H-indazol-4-yl]-4-methyl-2-morpholinecarboxamide
  参考文献：
  名称：

  Compounds

  摘要：

  本发明涉及某些新型化合物，涉及式（I）化合物及其盐。本发明的化合物是PI3-激酶活性抑制剂。

  公开号：

  US08536169B2

文献信息

• [EN] NOVEL COMPOUNDS<br/>[FR] NOUVEAUX COMPOSÉS
  申请人：GLAXO GROUP LTD

  公开号：WO2009147189A1

  公开（公告）日：2009-12-10

  The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I) and salts thereof. The compounds of the invention are inhibitors of PI3-kinase activity.

  这项发明涉及某些新颖化合物。具体而言，该发明涉及式(I)的化合物及其盐。该发明的化合物是PI3-激酶活性的抑制剂。
• Indazole derivatives
  申请人：Ohta Yoshihisa

  公开号：US20070117856A1

  公开（公告）日：2007-05-24

  The present invention provides a compound represented by Formula (I): [wherein R 1 represents CONR 1a R 1b (wherein R 1a and R 1b may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, substituted or unsubstituted ararkyl or a substituted or unsubstituted heterocyclic group, or R 1a and R 1b are combined together with the adjacent nitrogen atom thereto to form a substituted or unsubstituted heterocyclic group) or the like, R 2 represents a hydrogen atom, CONR 2a R 2b (wherein R 2a and R 2b may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, substituted or unsubstituted ararkyl or a substituted or unsubstituted heterocyclic group, or R 2a and R 2b are combined together with the adjacent nitrogen atom thereto to form a substituted or unsubstituted heterocyclic group), NR 2c R 2d (wherein R 2c and R 2d may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkanoyl, substituted or unsubstituted aroyl, substituted or unsubstituted heteroaroyl, substituted or unsubstituted ararkyl, substituted or unsubstituted lower alkylsulfonyl or substituted or unsubstituted lower arylsulfonyl) or the like].

  本发明提供了一个由公式（I）表示的化合物：[其中R1表示CONR1aR1b（其中R1a和R1b可以相同或不同，每个表示氢原子，取代或未取代的较低烷基，取代或未取代的芳基，取代或未取代的芳基烷基或取代或未取代的杂环基，或R1a和R1b与相邻的氮原子结合形成取代或未取代的杂环基）或类似物，R2表示氢原子，CONR2aR2b（其中R2a和R2b可以相同或不同，每个表示氢原子，取代或未取代的较低烷基，取代或未取代的芳基，取代或未取代的芳基烷基或取代或未取代的杂环基，或R2a和R2b与相邻的氮原子结合形成取代或未取代的杂环基），NR2cR2d（其中R2c和R2d可以相同或不同，每个表示氢原子，取代或未取代的较低烷基，取代或未取代的较低烷酰基，取代或未取代的芳酰基，取代或未取代的杂环芳酰基，取代或未取代的芳基烷基磺酰基或取代或未取代的较低芳基磺酰基）或类似物]。
• INDAZOLE DERIVATIVES
  申请人：Ohta Yoshihisa

  公开号：US20090082348A1

  公开（公告）日：2009-03-26

  The present invention provides a compound represented by Formula (I): [wherein R 1 represents CONR 1a R 1b (wherein R 1a and R 1b may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, substituted or unsubstituted ararkyl or a substituted or unsubstituted heterocyclic group, or R 1a and R 1b are combined together with the adjacent nitrogen atom thereto to form a substituted or unsubstituted heterocyclic group) or the like, R 2 represents a hydrogen atom, CONR 2a R 2b (wherein R 2a and R 2b may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, substituted or unsubstituted ararkyl or a substituted or unsubstituted heterocyclic group, or R 2a and R 2b are combined together with the adjacent nitrogen atom thereto to form a substituted or unsubstituted heterocyclic group), NR 2c R 2d (wherein R 2c and R 2d may be the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkanoyl, substituted or unsubstituted aroyl, substituted or unsubstituted heteroaroyl, substituted or unsubstituted ararkyl, substituted or unsubstituted lower alkylsulfonyl or substituted or unsubstituted lower arylsulfonyl) or the like].

  本发明提供了一个由公式（I）表示的化合物：[其中R1表示CONR1aR1b（其中R1a和R1b可以相同或不同，每个代表氢原子，取代或未取代的较低烷基，取代或未取代的芳基，取代或未取代的芳基烷基或取代或未取代的杂环基，或R1a和R1b与相邻的氮原子结合形成取代或未取代的杂环基）或类似物，R2表示氢原子，CONR2aR2b（其中R2a和R2b可以相同或不同，每个代表氢原子，取代或未取代的较低烷基，取代或未取代的芳基，取代或未取代的芳基烷基或取代或未取代的杂环基，或R2a和R2b与相邻的氮原子结合形成取代或未取代的杂环基），NR2cR2d（其中R2c和R2d可以相同或不同，每个代表氢原子，取代或未取代的较低烷基，取代或未取代的较低烷酰基，取代或未取代的芳酰基，取代或未取代的杂环芳酰基，取代或未取代的芳基烷基磺酰基或取代或未取代的芳基磺酰基）或类似物]。
• Novel Compounds
  申请人：Baldwin Ian Robert

  公开号：US20110183973A1

  公开（公告）日：2011-07-28

  The invention is directed to certain novel compounds directed to compounds of formula (I) and salts thereof. The compounds of the invention are inhibitors of PI3-kinase activity.

  本发明涉及某些新型化合物，这些化合物为式（I）化合物及其盐。本发明的化合物是PI3-激酶活性的抑制剂。
• NOVEL COMPOUNDS
  申请人：Glaxo Group Limited

  公开号：EP2280705B1

  公开（公告）日：2014-10-08