2-[4-(dimethylamino)phenyl]imidazo[1,2-a]pyridine-8-ol | 1196457-43-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-[4-(dimethylamino)phenyl]imidazo[1,2-a]pyridine-8-ol
• 英文别名: 2-[4-(Dimethylamino)phenyl]imidazo[1,2-alpha]pyridine-8-ol；2-[4-(dimethylamino)phenyl]imidazo[1,2-a]pyridin-8-ol
• CAS: 1196457-43-8
• 化学式: C₁₅H₁₅N₃O
• 分子量: 253.304
• InChiKey: WZQCIFBZGOOLJA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  40.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  二甲氨基苯乙酮 在 二乙基亚磷酸氢酯 、 硫酸 、 溴 、 三乙胺 作用下， 以 四氢呋喃 、 乙醇 为溶剂， 反应 19.0h， 生成 2-[4-(dimethylamino)phenyl]imidazo[1,2-a]pyridine-8-ol
  参考文献：
  名称：

  [EN] COMPOSITIONS AND METHODS FOR THE TREATMENT AND ANALYSIS OF NEUROLOGICAL DISORDERS
  [FR] COMPOSITIONS ET MÉTHODES DE TRAITEMENT ET D'ANALYSE DE TROUBLES NEUROLOGIQUES

  摘要：

  本文提供了用于治疗和分析神经系统疾病的组合物和方法。特别地，本文提供了针对淀粉样蛋白-β（Aβ）或金属-Aβ物种的小分子，用于治疗、诊断或研究阿尔茨海默病（AD）和其他疾病和病况等神经系统疾病。

  公开号：

  WO2013082508A1

文献信息

• [EN] PROCHELATORS USEFUL FOR INHIBITING METAL-ASSOCIATED TOXICITY<br/>[FR] PROCHÉLATEURS UTILISABLES À DES FINS D'INHIBITION DE LA TOXICITÉ ASSOCIÉE AUX MÉTAUX
  申请人：UNIV DUKE

  公开号：WO2011011597A1

  公开（公告）日：2011-01-27

  Prochelator compounds of Formula (I) or Formula (II) are described, along with methods of using the same and pharmaceutical formulations or compositions containing the same.

  本文描述了化合物公式（I）或公式（II）的Prochelator化合物，以及使用它们的方法和包含它们的制药配方或组合物。
• COMPOSITIONS AND METHODS FOR THE TREATMENT AND ANALYSIS OF NEUROLOGICAL DISORDERS
  申请人：THE REGENTS OF THE UNIVERSITY OF MICHIGAN

  公开号：US20140335019A1

  公开（公告）日：2014-11-13

  Provided herein are compositions and methods for the treatment and analysis of neurological disorders. In particular, provided herein are small molecules targeted to amyloid-β (Aβ) or metal-Aβ species for the treatment, diagnosis, or study of neurological conditions such as Alzheimer's disease (AD) and other diseases and conditions.

  本文提供了用于治疗和分析神经系统疾病的组合物和方法。具体来说，本文提供了针对淀粉样蛋白-β（Aβ）或金属-Aβ物种的小分子，用于治疗、诊断或研究阿尔茨海默病（AD）和其他疾病和病况等神经系统疾病。
• Small Molecule Modulators of Copper-Induced Aβ Aggregation
  作者：Sarmad S. Hindo、Allana M. Mancino、Joseph J. Braymer、Yihong Liu、Subramanian Vivekanandan、Ayyalusamy Ramamoorthy、Mi Hee Lim

  DOI：10.1021/ja907045h

  日期：2009.11.25

  Our design of bifunctional metal chelators as chemical probes and potential therapeutics for Alzheimer's disease (AD) is based on the incorporation of a metal binding moiety into structural frameworks of AB aggregate-imaging agents. Using this strategy, two compounds 2-[4-(dimethylamino)phenyl]imidazo[1,2-a]pyridine-8-ol (1) and N-1,N-1-dimethyl-N-4-(pyridin-2-ylmethylene)benzene-1,4-diamine (2) were prepared and characterized. The bifunctionality for metal chelation and AB interaction of 1 and 2 was verified by spectroscopic methods. Furthermore, the reactivity of 1 and 2 with Cu-II-associated AB aggregates was investigated. The modulation of Cu-II-triggered AB aggregation by 1 and 2 was found to be more effective than that by the known metal chelating agents CQ, EDTA, and phen. These studies suggest a new class of multifunctional molecules for the development of chemical tools to unravel metal-associated events in AD and potential therapeutic agents for metat-ion chetation therapy.
• PROCHELATORS USEFUL FOR INHIBITING METAL-ASSOCIATED TOXICITY
  申请人：Franz Katherine J.

  公开号：US20130096085A1

  公开（公告）日：2013-04-18

  Prochelator compounds of Formula (I) or Formula (II) are described, along with methods of using the same and pharmaceutical formulations or compositions containing the same.
• US8680077B2
  申请人：——

  公开号：US8680077B2

  公开（公告）日：2014-03-25