6-O-acetyl-2-azido-2-deoxy-3,4-di-O-methyl-α,β-D-glucopyranose trichloroacetimidate | 150126-03-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 6-O-acetyl-2-azido-2-deoxy-3,4-di-O-methyl-α,β-D-glucopyranose trichloroacetimidate
• 英文别名: [(2R,3S,4R,5R)-5-azido-3,4-dimethoxy-6-(2,2,2-trichloroethanimidoyl)oxyoxan-2-yl]methyl acetate
• CAS: 150126-03-7
• 化学式: C₁₂H₁₇Cl₃N₄O₆
• 分子量: 419.649
• InChiKey: RZGFJNZWYHPMJA-WWGUJXLXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  25
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  101
• 氢给体数：
  1
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  6-O-acetyl-2-azido-2-deoxy-3,4-di-O-methyl-α,β-D-glucopyranose trichloroacetimidate 、 methyl(methyl 2,3-di-O-methyl-β-D-glucopyranosyluronate)-(1-4)-(2,3,6-tri-O-acetyl-α-D-glucopyranosyl)-(1-4)-(methyl 2,3-di-O-methyl-α-L-idopyranosyluronate)-(1-4)-2,3,6-tri-O-acetyl-α-D-glucopyranoside 在 叔丁基二甲硅基三氟甲磺酸酯 作用下， 以 乙醚 、 二氯甲烷 为溶剂， 反应 0.67h， 生成 methyl(6-O-acetyl-2-azido-2-deoxy-3,4-di-O-methyl-α-D-glucopyranosyl)-(1-4)-(methyl 2,3-di-O-methyl-β-D-glucopyranosyluronate)-(1-4)-(2,3,6-tri-O-acetyl-α-D-glucopyranosyl)-(1-4)-(methyl 2,3,6-tri-O-methyl-α-L-idopyranosyluronate)-(1-4)-2,3,6-tri-O-acetyl-α-D-glucopyranoside
  参考文献：
  名称：

  Novel polysaccharides with antithrombotic activity comprising at least one covalent bond with biotin or a biotin derivative

  摘要：

  本发明涉及具有抗血栓活性的新型合成多糖，其至少与生物素或生物素衍生物之一形成共价键，以及利用亲和素或链球菌素的过程，使得可以中和这些多糖。

  公开号：

  US20060160768A1

文献信息

• ANTICOAGULANT COMPOUNDS
  申请人：Petitou Maurice

  公开号：US20100081708A1

  公开（公告）日：2010-04-01

  The present invention is concerned with anticoagulants (i.e. substances that stop blood from clotting). More specifically, the present invention is concerned with orally available antithrombic oligosaccharides.

  本发明涉及抗凝剂（即阻止血液凝结的物质）。更具体地说，本发明涉及口服可用的抗血栓寡糖。
• Polysaccharides with antithrombotic activity comprising at least a covalent bond with biotin or a biotin derivative
  申请人：——

  公开号：US20040024197A1

  公开（公告）日：2004-02-05

  The present invention relates to novel synthetic polysaccharides with antithrombotic activity exhibiting at least one covalent bond with biotin or a biotin derivative and to a process employing avidin or streptavidin which makes it possible to neutralize these polysaccharides.

  本发明涉及具有抗血栓活性的新型合成多糖，这些多糖与生物素或生物素衍生物至少有一个共价键，本发明还涉及一种使用阿维菌素或链霉亲和素的工艺，这种工艺可以中和这些多糖。
• POLYSACCHARIDES A ACTIVITE ANTITHROMBOTIQUE COMPRENANT AU MOINS UNE LIAISON COVALENTE AVEC LA BIOTINE OU UN DERIVE DE LA BIOTINE
  申请人：Sanofi-Aventis

  公开号：EP1322673B1

  公开（公告）日：2007-09-26
• Novel Polysaccharides with Antithrombotic Activity Comprising at Least One Covalent Bond with Biotin or a Biotin Derivative
  申请人：Duchaussoy Philippe

  公开号：US20110144042A1

  公开（公告）日：2011-06-16

  The present invention relates to novel synthetic polysaccharides with antithrombotic activity exhibiting at least one covalent bond with biotin or a biotin derivative and to a process employing avidin or streptavidin which makes it possible to neutralize these polysaccharides.
• US6844329B2
  申请人：——

  公开号：US6844329B2

  公开（公告）日：2005-01-18