4-[3-(1-ethylpropyl)-3H-imidazole-4-carbonyl]benzonitrile | 1450739-37-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-[3-(1-ethylpropyl)-3H-imidazole-4-carbonyl]benzonitrile
• 英文别名: 4-[3-(1-ethylpropyl)-3H-imidazol-4-carbonyl]benzonitrile；4-(3-Pentan-3-ylimidazole-4-carbonyl)benzonitrile
• CAS: 1450739-37-3
• 化学式: C₁₆H₁₇N₃O
• 分子量: 267.33
• InChiKey: RCSXUDGRVOMMCH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  58.7
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• [EN] IMIDAZOLYLKETONE DERIVATIVES ASD ALDOSTERONE SYNTHASE INHIBITORS<br/>[FR] DÉRIVÉS D'IMIDAZOLYLCÉTONE EN TANT QU'INHIBITEURS DE L'ALDOSTÉRONE SYNTHASE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2013120771A1

  公开（公告）日：2013-08-22

  The invention provides novel compounds having the general formula (I), wherein R1, R2, R3 and R4 n are as described herein, compositions including the compounds and methods of using the compounds as inhibitors of aldosterone synthase.

  这项发明提供了具有一般式(I)的新化合物，其中R1、R2、R3和R4 n如本文所述，包括这些化合物的组合物以及将这些化合物用作醛固酮合成酶抑制剂的方法。
• NEW IMIDAZOLYLKETONE DERIVATIVES
  申请人：HOFFMANN-LA ROCHE INC.

  公开号：US20140128429A1

  公开（公告）日：2014-05-08

  The invention provides novel compounds having the general formula (I) wherein R 1 , R 2 , R 3 and R 4 n are as described herein, compositions including the compounds and methods of using the compounds.

  这项发明提供了具有一般式（I）的新化合物，其中R1、R2、R3和R4n如本文所述，包括这些化合物的组合物以及使用这些化合物的方法。
• Strong reversible hydrogels
  申请人：SupraPolix B.V.

  公开号：US10377847B2

  公开（公告）日：2019-08-13

  The present invention relates to improved hydrogel materials using water gellants that are comprised of polymer backbones P to which hydrogen bonding 4H-units are covalently attached via a hydrophobic linker L. Optionally, the hydrogel contains additional ingredients or additives. These new reversible hydrogels can easily be fine-tuned in their mechanical performance and function and are especially suitable for biomedical applications.

  本发明涉及使用水胶凝剂的改进型水凝胶材料，该材料由聚合物骨架 P 组成，氢键 4H 单元通过疏水连接剂 L 共价连接到聚合物骨架 P 上。这些新型可逆水凝胶可以很容易地对其机械性能和功能进行微调，尤其适用于生物医学应用。
• IMIDAZOLYLKETONE DERIVATIVES ASD ALDOSTERONE SYNTHASE INHIBITORS
  申请人：F. Hoffmann-La Roche AG

  公开号：EP2814814B1

  公开（公告）日：2019-05-08
• STRONG REVERSIBLE HYDROGELS
  申请人：SupraPolix B.V.

  公开号：US20140128482A1

  公开（公告）日：2014-05-08

  The present invention relates to improved hydrogel materials using water gellants that are comprised of polymer backbones P to which hydrogen bonding 4H-units are covalently attached via a hydrophobic linker L. Optionally, the hydrogel contains additional ingredients or additives. These new reversible hydrogels can easily be fine-tuned in their mechanical performance and function and are especially suitable for biomedical applications.