(4aR,6R,7S,8S,8aS)-7-Amino-6-methoxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-8-ol | 25605-61-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (4aR,6R,7S,8S,8aS)-7-Amino-6-methoxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-8-ol
• 英文别名: (4Ar,6R,7S,8S,8aS)-7-amino-6-methoxy-2-phenyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-8-ol
• CAS: 25605-61-2
• 化学式: C₁₄H₁₉NO₅
• 分子量: 281.309
• InChiKey: GQJOKDVZCWTBHR-ORIPSZCPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  83.2
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• Process for the preparation of cyclopropane carboxylic acid esters
  申请人：IMPERIAL CHEMICAL INDUSTRIES PLC

  公开号：EP0023075A1

  公开（公告）日：1981-01-28

  3-(Halogenovinyl- or propenyl-)-2,2-dimethyl cyclopropane-1-carboxylic acid esters, which are precursors of, or may themselves be, pyrethroid insecticides, are prepared by the reaction of certain halogenopentadienes with an alkyl diazoacetate in the presence of a catalyst which is a transition metal complex of certain chiral Schiff bases, which catalysts tend to increase the yield of preferred cis IR isomer relative to the other possible isomers.

  3-(卤代乙烯基-或丙烯基-)-2,2-二甲基环丙烷-1-羧酸酯是拟除虫菊酯类杀虫剂的前体，或其本身可能是拟除虫菊酯类杀虫剂，其制备方法是某些卤代戊二烯与重氮乙酸烷基酯在催化剂存在下发生反应，催化剂是某些手性席夫碱的过渡金属络合物，相对于其他可能的异构体，这些催化剂倾向于增加优选顺式红外异构体的产率。
• Chiral sugar complexes and process for their preparation
  申请人：IMPERIAL CHEMICAL INDUSTRIES PLC

  公开号：EP0024797A1

  公开（公告）日：1981-03-11

  Chiral Schiff bases according to the general formula: and chiral transition metal complexes thereof, wherein at least the carbon atom of the monosaccharide to which the iminyl nitrogen atom is attached is asymmetric, and at least one of the carbon atoms adjacent the aforesaid carbon atom bears a hydroxyl group, R1 and R6 which may be the same or different, are hydrogen or lower alkyl, R2 is hydrogen, or lower alkyl or together with R10 forms a divalent hydrocarbon group, R3 is hydrogen, a sugar residue, or-CH2OR10 in which R10 is hydrogen, lower alkyl or together with R2 forms a divalent hydrocarbon group, R4 is hydrogen or-CH2OR10 in which R10 is hydrogen, or a lower alkyl, R5 is hydrogen, OR1 or a sugar residue, provided that both R4 and R5 are not hydrogen, R7 and R8 which may be the same or different, are hydrogen, or lower alkyl, or where p is 1, may with the cyclic ring to which CR7R8 is attached form a fused system, R8 is hydrogen, alkyl, aralkyl, aryl or alkaryl, J is a chain of 3 or 4 atoms which with the group CK forms an aromatic system, which atoms may be carbon atoms or may be a mixture of carbon and one or more hetero atoms which may be the same or different, K is nitrogen, or =COH, =→O or -NH-, L each of which may be the same or different, represents a substituent attached to a carbon atom in the chain J and is hydrogen, an alkyl group, aralkyl group, aryl, alkaryl or a substituent containing a hetero-atom; or two L's together with cyclic group to which they are attached form a fused system, m is 0 or 1, n is 0,1 or 2, provided that n plus m is 0, 1, 2 or 3, p is 0, 1 or 2 and q is the number of carbon atoms in the chain J. Thetransition metal is for example copper (II), chromium (II), manganese (II), iron (II), cobalt (II), nickel (II) or palladium (II). The aforesaid complexes may be used as catalysts in the cyclopropanation of olefins by diazoacetates to form insecticide or insecticide precursors.

  根据通式的手性希夫碱： 及其手性过渡金属配合物，其中亚氨基氮原子所连接的单糖的至少一个碳原子是不对称的，与上述碳原子相邻的至少一个碳原子带有羟基，R1和R6可以相同或不同，是氢或低级烷基，R2是氢、R3 是氢、糖残基或-CH2OR10，其中 R10 是氢、低级烷基或与 R2 一起形成二价烃基；R4 是氢或-CH2OR10，其中 R10 是氢或低级烷基；R5 是氢、OR1 或糖残基，但 R4 和 R5 都不是氢、R7 和 R8 可以相同或不同，它们是氢、或低级烷基，或当 p 为 1 时，可与 CR7R8 所连接的环形成一个融合系统，R8 是氢、烷基、芳基、芳烷基或烷芳基，J 是 3 或 4 个原子的链，与基团 CK 形成一个芳香系统、其中的原子可以是碳原子，也可以是碳原子和一个或多个杂原子的混合物，杂原子可以是相同的，也可以是不同的；K 是氮，或 =COH、=→O 或 -NH-；L 每个可以是相同的，也可以是不同的，代表连接到链 J 中一个碳原子上的取代基，是氢、烷基、芳基、芳烷基或含有杂原子的取代基；或两个 L 与所连接的环状基团一起形成一个融合体系，m 为 0 或 1，n 为 0、1 或 2，条件是 n 加 m 为 0、1、2 或 3，p 为 0、1 或 2，q 为链 J 中的碳原子数。过渡金属例如为铜（II）、铬（II）、锰（II）、铁（II）、钴（II）、镍（II）或钯（II）。上述配合物可用作重氮乙酸酯环丙烷化烯烃的催化剂，以形成杀虫剂或杀虫剂前体。
• US4288387A
  申请人：——

  公开号：US4288387A

  公开（公告）日：1981-09-08
• US4350811A
  申请人：——

  公开号：US4350811A

  公开（公告）日：1982-09-21
• US4344894A
  申请人：——

  公开号：US4344894A

  公开（公告）日：1982-08-17