5-Hydroxymethyl-3-<β-D-glucopyranosyl>-uracil | 92027-00-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5-Hydroxymethyl-3-<β-D-glucopyranosyl>-uracil
• 英文别名: 5-hydroxymethyl-1-α-L-idopyranosyl-1H-pyrimidine-2,4-dione；5-(hydroxymethyl)-1-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]pyrimidine-2,4-dione
• CAS: 92027-00-4
• 化学式: C₁₁H₁₆N₂O₈
• 分子量: 304.257
• InChiKey: IMEFOSQNPPAEJN-HPFNVAMJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.9
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  160
• 氢给体数：
  6
• 氢受体数：
  8

文献信息

• MULTIMER GLYCOSYLATED NUCLEIC ACID BINDING PROTEIN CONJUGATES AND USES THEREOF
  申请人：Schmidt Karsten

  公开号：US20120276548A1

  公开（公告）日：2012-11-01

  The technology relates in part to multimer conjugates comprising a scaffold linked to two or more polypeptides that specifically interact with a nucleic acid containing beta-D-glucosyl-hydroxymethylcytosine or beta-D-glucosyl-hydroxymethyluracil. The scaffold can be chosen from an antibody, an antibody fragment, a multimerized binding partner that interacts with a binding partner counterpart in each of the polypeptides, a polymer, and a polyfunctional molecule. The polypeptides can be from a kinetoplastid flagellate organism and may comprise a full-length native or modified protein or a fragment thereof that specifically interacts with the beta-D-glucosyl-hydroxymethylcytosine and/or the beta-D-glucosyl-hydroxymethyluracil in the nucleic acid. The conjugates provided herein can be used to detect the presence, absence or amount of beta-D-glucosyl-hydroxymethylcytosine and/or beta-D-glucosyl-hydroxymethyluracil-containing nucleic acid in a sample.

  该技术涉及部分包含一个支架的多聚物共轭物，该支架连接到两个或更多与含有β-D-葡糖基-羟甲基胞嘧啶或β-D-葡糖基-羟甲基尿嘧啶的核酸特异相互作用的多肽。支架可以选择自抗体、抗体片段、与每个多肽中的结合伙伴对应的结合伙伴相互作用的多聚化结合伙伴、聚合物和多功能分子。多肽可以来自运动类鞭毛原虫生物，可能包括一个全长的天然或修饰的蛋白质，或者一个与核酸中的β-D-葡糖基-羟甲基胞嘧啶和/或β-D-葡糖基-羟甲基尿嘧啶特异相互作用的片段。本文提供的共轭物可用于检测样品中含有β-D-葡糖基-羟甲基胞嘧啶和/或β-D-葡糖基-羟甲基尿嘧啶的核酸的存在、缺失或数量。
• Compositions and Methods for the Transfer of a Hexosamine to a Modified Nucleotide in a Nucleic Acid
  申请人：New England Biolads, Inc.

  公开号：US20140127677A1

  公开（公告）日：2014-05-08

  Nucleic acids comprising β-glucosaminyloxy-5-methylcytosine; compositions, kits and methods of producing the nucleic acids using a glycosyltransferase; and methods of using the nucleic acids are described.
• US8951736B2
  申请人：——

  公开号：US8951736B2

  公开（公告）日：2015-02-10
• US9200260B2
  申请人：——

  公开号：US9200260B2

  公开（公告）日：2015-12-01
• [EN] MULTIMER GLYCOSYLATED NUCLEIC ACID BINDING PROTEIN CONJUGATES AND USES THEREOF<br/>[FR] CONJUGUÉS MULTIMÈRES DE PROTÉINES GLYCOSYLÉES DE LIAISON À L'ACIDE NUCLÉIQUE ET LEURS UTILISATIONS
  申请人：SEQUENOM INC

  公开号：WO2012149047A1

  公开（公告）日：2012-11-01

  The technology relates in part to multimer conjugates comprising a scaffold linked to two or more polypeptides that specifically interact with a nucleic acid containing beta-D- glucosyl-hydroxymethylcytosine or beta-D-glucosyl-hydroxymethyluracil. The scaffold can be chosen from an antibody, an antibody fragment, a multimerized binding partner that interacts with a binding partner counterpart in each of the polypeptides, a polymer, and a polyfunctional molecule. The polypeptides can be from a kinetoplastid flagellate organism and may comprise a full-length native or modified protein or a fragment thereof that specifically interacts with the beta-D-glucosyl-hydroxymethylcytosine and/or the beta-D-glucosyl-hydroxymethyluracil in the nucleic acid. The conjugates provided herein can be used to detect the presence, absence or amount of beta-D-glucosyl-hydroxymethylcytosine and/or beta-D-glucosyl-hydroxymethyluracil-containing nucleic acid in a sample.