methyl 6-deoxy-6-(4-phenylbutyl)amino-β-D-galactopyranose | 156237-17-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: methyl 6-deoxy-6-(4-phenylbutyl)amino-β-D-galactopyranose
• 英文别名: (2R,3R,4S,5R,6R)-2-methoxy-6-[(4-phenylbutylamino)methyl]oxane-3,4,5-triol
• CAS: 156237-17-1
• 化学式: C₁₇H₂₇NO₅
• 分子量: 325.405
• InChiKey: KAWOQNWXYBBBJF-DRRXZNNHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  23
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  91.2
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• Acylaminosaccharide derivative and process for preparing the same
  申请人：TANABE SEIYAKU CO., LTD.

  公开号：EP0650974A1

  公开（公告）日：1995-05-03

  There are disclosed an acylaminosaccharide derivative represented by the formula (I):    wherein R¹ is H, aryl or heterocyclic; X is a mere bond, alkylene, alkenylene or alkynylene; R² is (1) H, (2) aryl or heterocyclic, (3) aryl lower alkylcarbamoyl, (4) substituted carbonyl, or (5) carboxyl which may be esterified; Y is a mere bond, alkylene, alkenylene, alkynylene or tricycloalkylene; R³ and R⁴ are different and either hydrogen, or lower alkoxy or phenoxy; R⁵ and R⁶ are different and either hydrogen or hydroxy; and when R⁷ is hydroxy, R⁸ and R⁹ are different and either hydrogen or hydroxy, or when R⁷ and R⁸ are bonded to each other to form lower alkylenedioxy, R⁹ is hydrogen, or a pharmaceutically acceptable salt thereof, and a process for preparing the same.

  公开了一种由式（I）表示的酰胺糖衍生物：其中R¹为氢、芳基或杂环基；X为仅为键、烷基、烯基或炔基；R²为（1）氢、（2）芳基或杂环基、（3）芳基较低烷基氨基甲酰、（4）取代的羰基或（5）羧基，其可以酯化；Y为仅为键、烷基、烯基、炔基或三环烷基；R³和R⁴不同，为氢、较低烷氧基或苯氧基；R⁵和R⁶不同，为氢或羟基；当R⁷为羟基时，R⁸和R⁹不同，为氢或羟基，或当R⁷和R⁸结合形成较低烷基二氧基时，R⁹为氢，或其药学上可接受的盐，以及制备该化合物的方法。