methyl (+/-)-5,5-dimethyl-1,3-thiazolidine-4-carboxylate | 85929-61-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: methyl (+/-)-5,5-dimethyl-1,3-thiazolidine-4-carboxylate
• 英文别名: 5,5-Dimethyl-thiazolidin-4-carbonsaeure-methylester；5,5-dimethyl-thiazolidine-4-carboxylic acid methyl ester；N,S-methanediyl-penicillamine methyl ester；5.5-Me2-thz-4-OMe；5,5-dimethyl-4-methoxycarbonylthiazolidine；Methyl 5,5-dimethyl-1,3-thiazolidine-4-carboxylate
• CAS: 85929-61-9
• 化学式: C₇H₁₃NO₂S
• mdl: MFCD09881017
• 分子量: 175.252
• InChiKey: VQAXIQTYFVLHJT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.857
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  methyl (+/-)-5,5-dimethyl-1,3-thiazolidine-4-carboxylate 以 二氯甲烷 为溶剂， 生成 3,3-dimethyl-7-oxo-6c-phenyl-(5rH)-4-thia-1-aza-bicyclo[3.2.0]heptane-2c-carboxylic acid methyl ester
  参考文献：
  名称：

  青霉素的一种新的合成方法。

  摘要：

  DOI：

  10.1021/ja01089a055
• 作为产物：
  描述：

  DL-青霉胺 生成 methyl (+/-)-5,5-dimethyl-1,3-thiazolidine-4-carboxylate
  参考文献：
  名称：

  Coesite inclusions in zircon from gneisses identified by laser Raman microspectrometer in ultrahigh pressure zone of Dabie Mountains, China

  摘要：

  The mineral inclusions in zircon from gneisses in ultra-high pressure (UHP) zone of the Dable Mountains were identified by using a laser Raman microspectrometer. Coesite occurs as inclusions in zircons from all types of gneiss. Other important minerals, such as jadeite, omphacite, aragonite, barite, and anhydrite were also found as inclusion minerals. These discoveries indicate that (i) gneissic country rocks had metamorphosed at the same time as the enclosed eclogites; and (ii) SO4-2-bearing fluids were present in the UHP metamorphic process, which is manifested by occurrence of barite and anhydrite coexisting with coesite.

  DOI：

  10.1007/bf02901171

文献信息

• Thrombin inhibitors
  申请人：Abbott GmbH & Co., KG

  公开号：US06740647B1

  公开（公告）日：2004-05-25

  Novel five-membered heterocyclic amidines, their preparation and use as competitive inhibitors of trypsin-like serine proteases, especially thrombin and kininogenases such as kallikrein. Pharmaceutical compositions which contain the compounds as active ingredients, and use of the compounds as thrombin inhibitors, anticoagulants and antiinflammatory agents.

  新型五元杂环胺基化物，其制备和用作胰蛋白酶样丝氨酸蛋白酶的竞争性抑制剂，特别是血栓素和激肽原酶如激肽原酶的抑制剂。含有这些化合物作为活性成分的药物组合物，以及将这些化合物用作血栓素抑制剂、抗凝剂和抗炎药剂。
• Synthesis of Penicillin Analogs, (---)-Methyl 6-epi-6-Bromobisnorpenicillanate and (+-)-Methyl 6-epi-6-Bromopenicillanate.
  作者：Nils Gunnar Johansson、Rolf Carlson、Christoffer Rappe、O. Hänninen、Jean Vialle、T. Anthonsen

  DOI：10.3891/acta.chem.scand.30b-0377

  日期：——

  The [(4-methoxycarbonylthiazolidino)carbonyl-dihalomethyl]phenylmercury compounds 2a,b and 5a,b have been synthesized. When heated in refluxing bromobenzene they form halogenated penicillin analogs. (--)-Methyl 6-epi-6-bromobisnorpenicillinate (3a) and methyl 6-epi-6-bromopenicillinates (6a,b) have been prepared and isolated.

  合成了[（4-甲氧基羰基噻唑烷）羰基-二卤甲基]苯基汞化合物2a，b和5a，b。在回流的溴苯中加热时，它们会形成卤代青霉素类似物。已经制备并分离了（-）-6-epi-6-溴双去甲膦酸甲酯（3a）和6-epi-6-溴openicilliates甲基（6a，b）。
• Neher et al., Helvetica Chimica Acta, 1946, vol. 29, p. 1874,1881
  作者：Neher et al.

  DOI：——

  日期：——
• Beitr�ge zur Kenntnis der Reaktionsf�higkeit des Penicillamins und seiner Derivate
  作者：Friedrich Asinger、Karl-Heinz Gluzek

  DOI：10.1007/bf00809375

  日期：1983.1
• Heterocyclic compounds containing nitrogen and sulfur, processes for their preparation and pharmaceutical compositions thereof
  申请人：RICHTER GEDEON VEGYESZETI GYAR R.T.

  公开号：EP0411775B1

  公开（公告）日：1996-03-13