Methyl-3-benzamido-4,6-O-benzyliden-3-deoxy-2-O-methansulfonyl-α-D-altropyranosid | 887229-21-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡喃二恶英
• 英文名称: Methyl-3-benzamido-4,6-O-benzyliden-3-deoxy-2-O-methansulfonyl-α-D-altropyranosid
• 英文别名: Methyl-3-benzamino-4,6-O-benzyliden-3-deoxy-2-O-methansulfonyl-α-D-altropyranosid；methyl 3-benzoylamino-O⁴,O⁶-(R)-benzylidene-O²-methanesulfonyl-α-D-3-deoxy-altropyranoside；[(4aR,6S,7S,8R,8aS)-8-benzamido-6-methoxy-2-phenyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-7-yl] methanesulfonate
• CAS: 887229-21-2
• 化学式: C₂₂H₂₅NO₈S
• 分子量: 463.508
• InChiKey: MVPPBUNYVUFQJC-JMBRVHAGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  32
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  118
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  Methyl-3-benzamido-4,6-O-benzyliden-3-deoxy-2-O-methansulfonyl-α-D-altropyranosid 在 吡啶 、 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 生成 2,3-Benzoylimino-4,6-benzyliden-2,3-didesoxy-methyl-α-D-allopyranosid
  参考文献：
  名称：

  1010.吡喃糖苷的2,3-表亚氨基衍生物的制备

  摘要：

  DOI：

  10.1039/jr9630005295

文献信息

• Method for Optimizing Post-Translational Modifications on Recombinant Proteins
  申请人：LESZCYNIECKA Magdalena

  公开号：US20160340706A1

  公开（公告）日：2016-11-24

  A method for optimizing post-translational modifications of recombinant proteins expressed in living cells is described. More particularly, a method for modulation of host proteins in living cells that control PTMs on recombinant proteins is described that has particularly useful applications in developing manufacturing process changes or in biosimilar development. The goal of this modulation is to produce a recipe for production of a recombinant protein in the new process or in the biosimilar that will produce a targeted PTM profile in the resulting protein product. In the method one or more modulators are selected, as from a modulator library, which affect the activity of host proteins. These modulators are added to media during production such that the resulting product matches the PTMs of the reference product. The ideal set of modulators and their concentrations are identified through a unique iterative process and the combined modulators and their concentrations constitute a recipe for growth media for the production of said recombinant protein. The methodology to obtain such a recipe described herein may then be used in many applications, such as optimizing new batches of recombinant protein drugs, developing biosimilar or bio-better drugs.
• US9868973B2
  申请人：——

  公开号：US9868973B2

  公开（公告）日：2018-01-16