5-(4-acetylaminophenyl)-N-[2-azabicyclo[2.2.1]hept-6-yl]-1,3-oxazole-2-carboxamide | 524017-92-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-(4-acetylaminophenyl)-N-[2-azabicyclo[2.2.1]hept-6-yl]-1,3-oxazole-2-carboxamide
• 英文别名: 5-(4-acetamidophenyl)-N-(2-azabicyclo[2.2.1]heptan-6-yl)-1,3-oxazole-2-carboxamide
• CAS: 524017-92-3
• 化学式: C₁₈H₂₀N₄O₃
• 分子量: 340.382
• InChiKey: ZQTBHIWDUVYFFY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  96.3
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Azabicyclic-substituted-heteroaryl compounds for the treatment of disease
  申请人：——

  公开号：US20030207913A1

  公开（公告）日：2003-11-06

  The invention provides compounds of Formula I: Azabicyclo-N(R 1 )—C(═X)—W  Formula I These compounds may be in the form of pharmaceutical salts or compositions, racemic mixtures, or pure enantiomers thereof. The compounds of Formula I are useful in pharmaceuticals in which &agr;7 is known to be involved.

  这项发明提供了Formula I的化合物： Azabicyclo-N(R1)—C(═X)—W  Formula I 这些化合物可以是药用盐或组合物的形式，或者是它们的消旋混合物，或者是纯对映体。Formula I的化合物在已知涉及α7的药物中是有用的。
• [EN] TETRACYCLIC HETEROCOMPOUNDS AS ESTROGEN RECEPTOR MODULATORS<br/>[FR] HETERO-COMPOSES TETRACYCLIQUES UTILISABLES COMME MODULATEURS DU RECEPTEUR DES OESTROGENES
  申请人：ORTHO MCNEIL PHARM INC

  公开号：WO2003053977A1

  公开（公告）日：2003-07-03

  The present invention is directed to novel heteroatom containing tetracyclic derivatives, pharmaceutical compositions containing them, their use in the treatment and / or prevention of disorders mediated by one or more estrogen receptors and processes for their preparation. The compounds of the invention are useful in the treatment and / or prevention of disorders associated with the depletion of estrogen such as hot flashes, vaginal dryness, osteopenia and osteoporosis; hormone sensitive cancers and hyperplasia of the breast, endometrium, cervix and prostate; endometriosis, uterine fibroids, osteoarthritis and as contraceptive agents, alone or in combination with a progestogen or progestogen antagonist.

  本发明涉及新型含杂原子的四环衍生物、含有它们的药物组合物、它们在治疗和/或预防由一个或多个雌激素受体介导的疾病中的使用以及它们的制备过程。该发明的化合物在治疗和/或预防与雌激素缺乏有关的疾病方面具有用处，例如潮热、阴道干燥、骨质疏松症和骨质疏松症；激素敏感性癌症和乳腺、子宫内膜、子宫颈和前列腺的增生；子宫内膜异位症、子宫肌瘤、骨关节炎以及作为避孕药物，单独使用或与孕激素或孕激素拮抗剂组合使用。
• AZABICYCLIC-SUBSTITUTED-HETEROARYL COMPOUNDS FOR THE TREATMENT OF DISEASE
  申请人：PHARMACIA & UPJOHN COMPANY

  公开号：EP1442041A1

  公开（公告）日：2004-08-04
• TETRACYCLIC HETEROCOMPOUNDS AS ESTROGEN RECEPTOR MODULATORS
  申请人：Ortho-McNeil Pharmaceutical, Inc.

  公开号：EP1467998A1

  公开（公告）日：2004-10-20
• US6919359B2
  申请人：——

  公开号：US6919359B2

  公开（公告）日：2005-07-19