| 1580516-51-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磺酸及其衍生物
• CAS: 1580516-51-3
• 化学式: C₁₃H₁₉F₃O₈S
• 分子量: 392.35
• InChiKey: BGPHVPRJLHXJOU-HOTMZDKISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.25
• 重原子数：
  25.0
• 可旋转键数：
  3.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  89.52
• 氢给体数：
  0.0
• 氢受体数：
  8.0

反应信息

• 作为反应物：
  描述：

  、 (2R,3S,4S)-3,4-双(苄氧基)-2-((苄氧基)甲基)四氢噻吩 以 四氢呋喃 为溶剂， 反应 72.0h， 以85%的产率得到C₃₈H₄₇O₈S⁽¹⁺⁾*CF₃O₃S^(1-)
  参考文献：
  名称：

  Practical Synthesis of Neoponkoranol and its Related Sulfonium Salt, an Optimised Protocol using Isopropylidene as an Effective Protecting Group

  摘要：

  A practical synthesis of neoponkoranol and its related sulfonium salt as potent a-glucosidase inhibitors has been developed in which the key step of coupling reaction was optimised by using isopropylidene as an effective protecting group. The characteristic intramolecular cyclisation of the coupling precursor previously encountered as a side reaction has not been detected and coupling yields were dramatically improved in the present study.

  DOI：

  10.3184/174751913x13823645011477
• 作为产物：
  描述：

  三氟甲磺酸酐 、 1,2-3,5-di-O-isopropylidene-α-D-glucofuranose 在 2,6-二甲基吡啶 作用下， 以 二氯甲烷 为溶剂， 反应 0.66h， 以91%的产率得到
  参考文献：
  名称：

  Practical Synthesis of Neoponkoranol and its Related Sulfonium Salt, an Optimised Protocol using Isopropylidene as an Effective Protecting Group

  摘要：

  A practical synthesis of neoponkoranol and its related sulfonium salt as potent a-glucosidase inhibitors has been developed in which the key step of coupling reaction was optimised by using isopropylidene as an effective protecting group. The characteristic intramolecular cyclisation of the coupling precursor previously encountered as a side reaction has not been detected and coupling yields were dramatically improved in the present study.

  DOI：

  10.3184/174751913x13823645011477