2-ethyl-3-chloro-1-propanol | 17658-30-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-ethyl-3-chloro-1-propanol
• 英文别名: 2-(Chloromethyl)butan-1-ol
• CAS: 17658-30-9
• 化学式: C₅H₁₁ClO
• mdl: MFCD19236513
• 分子量: 122.595
• InChiKey: FTHLZCMMRRXVTF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  7
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-ethyl-3-chloropropanal 在 sodium borohydrid 作用下， 以 甲醇 为溶剂， 生成 2-ethyl-3-chloro-1-propanol
  参考文献：
  名称：

  24-and 25-substituted avermectin and milbemycin derivatives

  摘要：

  新的阿维菌素和米尔贝霉素衍生物被披露，其中C-24和C-25碳原子被氢、烷基、烯基、取代烷基或取代烯基基团取代。这些化合物可以在4"-、5-、13-和23-位置进一步取代。通过裂解已知和适当保护的阿维菌素和米尔贝霉素化合物制备的新的C-24和C-25取代阿维菌素。这些新化合物是有效的抗寄生虫剂，特别是这些化合物是驱虫剂、杀虫剂和杀螨剂。

  公开号：

  US05830875A1

文献信息

• Methods of synthesis of polymers and copolymers from natural products
  申请人：Swift Graham

  公开号：US20060052577A1

  公开（公告）日：2006-03-09

  Described are polymers and copolymers containing sorbitol, citric acid, starch, aspartic acid, succinic anhydride, adipic acid mixtures thereof, methods of their synthesis and their uses.

  本文描述了含有山梨醇、柠檬酸、淀粉、天冬氨酸、琥珀酸酐、己二酸及其混合物的聚合物和共聚物，以及它们的合成方法和用途。
• 24- and 25-substituted avermectin and milbemycin derivatives
  申请人：MERCK & CO. INC.

  公开号：EP0428286A2

  公开（公告）日：1991-05-22

  Novel avermectin and milbemycin derivatives are disclosed, where the C-24 and C-25 carbon atoms are substituted by hydrogen, alkyl, alkenyl, substituted alkyl or substituted alkenyl groups. These compounds can be further substituted at the 4˝-, 5-, 13-, and 23-­positions. The new C-24 and C-25 substituted avermectin and milbemycin derivatives are prepared by cleavage of known and suitably protected avermectin and milbemycin compounds. The new compounds are potent anti-parasitic agents, in particular, the compounds are anthelmintic, insecticidal and acaricidal agents.

  公开了新型阿维菌素和米贝霉素衍生物，其中 C-24 和 C-25 碳原子被氢、烷基、烯基、取代烷基或取代烯基取代。这些化合物还可以在 4˝-、5-、13- 和 23-位上被进一步取代。新的 C-24 和 C-25 取代的阿维菌素和米尔贝霉素衍生物是通过裂解已知的并经过适当保护的阿维菌素和米尔贝霉素化合物制备的。这些新化合物是强效的抗寄生虫药剂，特别是具有驱虫、杀虫和杀螨作用。
• 4"-and 4'-alkylthio-avermectin derivatives
  申请人：MERCK & CO. INC.

  公开号：EP0506331A1

  公开（公告）日：1992-09-30

  Avermectin derivatives are disclosed wherein the 4˝-hydroxy group is replaced by a substituted alkylthio or acylthio group or an iodo group. These avermectin derivatives can be further derivatized at the 5- and 23-positions as ketoximes or O-substituted ketoximes. The 4˝-substituted avermectin derivatives are prepared from the 4˝- and 4′-trifluoromethanesulfonyl avermectin derivatives with halo- or sulfur-containing nucleophiles. The 4˝- and 4′-α-and β-trifluoromethane sulfonates are prepared selectively and converted into 4˝- or 4′-alkyl- or acylsulfides, or iodides using the appropriate sulfur-containing or iodine nucleophile. Substituted sulfoxy and sulfonyl substituents at the 4˝- and 4′-positions are prepared from oxidation of the corresponding substituted sulfides. The new compounds are potent anti-parasitic agents; in particular, the compounds are anthelmintic, insecticidal and acaricidal agents.

  已公开的阿维菌素衍生物中，4˝-羟基被取代的烷硫基或酰硫基或碘基所取代。这些阿维菌素衍生物可在 5-位和 23-位进一步衍生为酮肟或 O-取代酮肟。4˝ 取代的阿维菌素衍生物是由 4˝- 和 4′-三氟甲磺酰基阿维菌素衍生物与卤代或含硫亲核物制备而成。选择性地制备 4˝-和 4′-α-和 β-三氟甲烷磺酸盐，并使用适当的含硫或碘亲核剂将其转化为 4˝-或 4′-烷基或酰基硫化物或碘化物。在 4˝-和 4′-位置上的取代的磺氧基和磺酰基是通过氧化相应的取代的硫化物制备的。这些新化合物是强效的抗寄生虫剂，尤其是具有驱虫、杀虫和杀螨作用。
• Organic compound, crystal dielectric layer and capacitor
  申请人：Capacitor Sciences Incorporated

  公开号：US10026553B2

  公开（公告）日：2018-07-17

  The present disclosure provides an organic compound characterized by electronic polarizability and having a following general structural formula: where Core is an aromatic polycyclic conjugated molecule, R1 is group providing solubility of the organic compound in an organic solvent, n is 1, 2, 3, 4, 5, 6, 7 or 8, R2 is substitute located in apex positions, R3 and R4 are substitutes located in side (lateral) positions and, the core has flat anisometric form and the R2 substitutes are selected from hydrogen and electrophilic groups (acceptors) and R3 substitutes and R4 substitutes are independently selected from hydrogen and nucleophilic groups (donors) or vice versa R3 substitutes and R4 substitutes are independently selected from hydrogen and nucleophilic groups (donors) and R2 substitutes are selected from hydrogen and electrophilic groups (acceptors), and the substitutes R2, R3 and R4 cannot all be hydrogen.

  本公开提供了一种有机化合物，其特点是具有电子极化性，并具有以下结构通式： 其中 Core 是芳香族多环共轭分子，R1 是提供有机化合物在有机溶剂中溶解度的基团，n 是 1、2、3、4、5、6、7 或 8，R2 是位于顶点位置的取代基，R3 和 R4 是位于侧（横向）位置的取代基，并且、核心具有扁平异形，R2 取代基选自氢和亲电基团（受体），R3 取代基和 R4 取代基独立选自氢和亲核基团（供体），反之亦然，R3 取代基和 R4 取代基独立选自氢和亲核基团（供体），R2 取代基选自氢和亲电基团（受体），且取代基 R2、R3 和 R4 不能都是氢。
• ORGANIC COMPOUND, CRYSTAL DIELECTRIC LAYER AND CAPACITOR
  申请人：Capacitor Sciences Incorporated

  公开号：US20170117097A1

  公开（公告）日：2017-04-27

  The present disclosure provides an organic compound characterized by electronic polarizability and having a following general structural formula: where Core is an aromatic polycyclic conjugated molecule, R 1 is group providing solubility of the organic compound in an organic solvent, n is 1, 2, 3, 4, 5, 6, 7 or 8, R 2 is substitute located in apex positions, R3 and R4 are substitutes located in side (lateral) positions and, the core has flat anisometric form and the R 2 substitutes are selected from hydrogen and electrophilic groups (acceptors) and R 3 substitutes and R 4 substitutes are independently selected from hydrogen and nucleophilic groups (donors) or vice versa R 3 substitutes and R 4 substitutes are independently selected from hydrogen and nucleophilic groups (donors) and R 2 substitutes are selected from hydrogen and electrophilic groups (acceptors), and the substitutes R 2 , R 3 and R 4 cannot all be hydrogen.