2-(6-methoxy-9H-purin-9-yl)-1-phenylethanone | 1148034-25-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-(6-methoxy-9H-purin-9-yl)-1-phenylethanone
• 英文别名: 2-(6-Methoxy-9H-purine-9-yl)-1-phenylethanone；2-(6-methoxypurin-9-yl)-1-phenylethanone
• CAS: 1148034-25-6
• 化学式: C₁₄H₁₂N₄O₂
• 分子量: 268.275
• InChiKey: XWDNJJKBPCAOOK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  69.9
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  甲醇 、 2-(6-Chloro-purin-9-yl)-1-phenyl-ethanone 在 氨 作用下， 以57.6%的产率得到2-(6-methoxy-9H-purin-9-yl)-1-phenylethanone
  参考文献：
  名称：

  Design, synthesis and characterization of N9/N7-substituted 6-aminopurines as VEGF-R and EGF-R inhibitors

  摘要：

  In this study we report on the design, synthesis and biological characterization of novel N-9 or N-7 arylethanone-substituted 6-aminopurines and 6-methoxypurines, respectively, as EGF-R and VEGF-R. inhibitors. The compounds were initially profiled in a panel of 24 cancer-relevant protein kinases. Dependent on the regio-substitution of the purine core we found inhibition activity for EGF-R. and VEGF-R with IC50 values in the mu M range. The two novel N-9/N-7 2-(6-amino-purine)-1-(1H-indole-3-yl)ethanone derivatives were characterized in an enhanced panel of 78 kinases showing the N-9 derivative to also inhibit MNK1 and IRR while the N-7 isomer was found to be specific for VEGF-R2. (c) 2008 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2008.04.012

文献信息

• Design, synthesis and characterization of N9/N7-substituted 6-aminopurines as VEGF-R and EGF-R inhibitors
  作者：Christian Peifer、Stefanie Bühler、Dominik Hauser、Katrin Kinkel、Frank Totzke、Christoph Schächtele、Stefan Laufer

  DOI：10.1016/j.ejmech.2008.04.012

  日期：2009.4

  In this study we report on the design, synthesis and biological characterization of novel N-9 or N-7 arylethanone-substituted 6-aminopurines and 6-methoxypurines, respectively, as EGF-R and VEGF-R. inhibitors. The compounds were initially profiled in a panel of 24 cancer-relevant protein kinases. Dependent on the regio-substitution of the purine core we found inhibition activity for EGF-R. and VEGF-R with IC50 values in the mu M range. The two novel N-9/N-7 2-(6-amino-purine)-1-(1H-indole-3-yl)ethanone derivatives were characterized in an enhanced panel of 78 kinases showing the N-9 derivative to also inhibit MNK1 and IRR while the N-7 isomer was found to be specific for VEGF-R2. (c) 2008 Elsevier Masson SAS. All rights reserved.