methyl N-(6-benzoylimidazo[1,2-a]pyridin-2-yl)carbamate | 79567-64-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: methyl N-(6-benzoylimidazo[1,2-a]pyridin-2-yl)carbamate
• CAS: 79567-64-9
• 化学式: C₁₆H₁₃N₃O₃
• 分子量: 295.298
• InChiKey: DXGHSJGKVQZPHH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  72.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-氯-5-苯甲酰吡啶 在 六甲基磷酰三胺 、 氨 作用下， 反应 1.5h， 生成 methyl N-(6-benzoylimidazo[1,2-a]pyridin-2-yl)carbamate
  参考文献：
  名称：

  Substituted imidazo[1,2-a]pyridine-2-carbamate anthelmintics

  摘要：

  Anthelmintic efficacies of a series of 6-substituted methyl imidazo[1,2-alpha]pyridine-2-carbamates were compared to similarly substituted benzimidazole-2-carbamates. With only one exception, methyl 6-benzoylimidazo[1,2-alpha]pyridine-2-carbamate, both classes of compounds exhibited similar activity vs. Nematospiroides dubius in mice. Preliminary screening indicated methyl 6-(1,2,2-trichloroethenyl)imidazo[1,2-alpha]pyridine-2-carbamate to be the most potent derivative in the series. However, evaluation in sheep indicated that its anthelmintic spectrum was inferior to methyl 6-(phenylsulfinyl)imidazo[1,2-alpha]pyridine-2-carbamate.

  DOI：

  10.1021/jm00144a030

文献信息

• BOCHIS, R. J.;OLEN, L. E.;WAKSMUNSKI, F. S.;MROZIK, H.;ESKOLA, P.;KULSA, +, J. MED. CHEM., 1981, 24, N 12, 1518-1521
  作者：BOCHIS, R. J.、OLEN, L. E.、WAKSMUNSKI, F. S.、MROZIK, H.、ESKOLA, P.、KULSA, +

  DOI：——

  日期：——
• Substituted imidazo[1,2-a]pyridine-2-carbamate anthelmintics
  作者：Richard J. Bochis、Leonard E. Olen、Frank S. Waksmunski、Helmut Mrozik、Philip Eskola、Peter Kulsa、George Wilks、Joyce E. Taylor、John R. Egerton

  DOI：10.1021/jm00144a030

  日期：1981.12

  Anthelmintic efficacies of a series of 6-substituted methyl imidazo[1,2-alpha]pyridine-2-carbamates were compared to similarly substituted benzimidazole-2-carbamates. With only one exception, methyl 6-benzoylimidazo[1,2-alpha]pyridine-2-carbamate, both classes of compounds exhibited similar activity vs. Nematospiroides dubius in mice. Preliminary screening indicated methyl 6-(1,2,2-trichloroethenyl)imidazo[1,2-alpha]pyridine-2-carbamate to be the most potent derivative in the series. However, evaluation in sheep indicated that its anthelmintic spectrum was inferior to methyl 6-(phenylsulfinyl)imidazo[1,2-alpha]pyridine-2-carbamate.