(3-chlorophenyl)(3-methyl-3H-imidazol-4-yl)methanone | 1450738-78-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (3-chlorophenyl)(3-methyl-3H-imidazol-4-yl)methanone
• 英文别名: (3-Chlorophenyl)-(3-methylimidazol-4-yl)methanone
• CAS: 1450738-78-9
• 化学式: C₁₁H₉ClN₂O
• 分子量: 220.658
• InChiKey: OLEGINBETAWOKE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  34.9
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• [EN] IMIDAZOLYLKETONE DERIVATIVES ASD ALDOSTERONE SYNTHASE INHIBITORS<br/>[FR] DÉRIVÉS D'IMIDAZOLYLCÉTONE EN TANT QU'INHIBITEURS DE L'ALDOSTÉRONE SYNTHASE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2013120771A1

  公开（公告）日：2013-08-22

  The invention provides novel compounds having the general formula (I), wherein R1, R2, R3 and R4 n are as described herein, compositions including the compounds and methods of using the compounds as inhibitors of aldosterone synthase.

  这项发明提供了具有一般式(I)的新化合物，其中R1、R2、R3和R4 n如本文所述，包括这些化合物的组合物以及将这些化合物用作醛固酮合成酶抑制剂的方法。
• NEW IMIDAZOLYLKETONE DERIVATIVES
  申请人：HOFFMANN-LA ROCHE INC.

  公开号：US20140128429A1

  公开（公告）日：2014-05-08

  The invention provides novel compounds having the general formula (I) wherein R 1 , R 2 , R 3 and R 4 n are as described herein, compositions including the compounds and methods of using the compounds.

  这项发明提供了具有一般式（I）的新化合物，其中R1、R2、R3和R4n如本文所述，包括这些化合物的组合物以及使用这些化合物的方法。
• METHOD FOR PRODUCING RUBBER COMPOSITION FOR TIRES, AND PNEUMATIC TIRE
  申请人：Sumitomo Rubber Industries, Ltd.

  公开号：EP3144341A1

  公开（公告）日：2017-03-22

  According to the process of the present invention for preparing a rubber composition for a tire comprising a rubber component (A) comprising a natural rubber and/or a synthetic diene rubber, a filler comprising an inorganic filler (B) at least comprising silica, a silane coupling agent (C) and a peptizing agent (D), a rubber composition for a tire having improved processability, abrasion resistance and fuel efficiency in a good balance and a pneumatic tire produced using the rubber composition for a tire prepared by the preparation process can be provided.

  根据本发明制备轮胎橡胶组合物的工艺，该轮胎橡胶组合物包含由天然橡胶和/或合成二烯橡胶组成的橡胶组分（A）、由至少包含白炭黑的无机填料（B）、硅烷偶联剂（C）和发泡剂（D）组成的填料，可以提供一种加工性、耐磨性和燃油效率得到良好平衡改善的轮胎橡胶组合物，以及使用该制备工艺制备的轮胎橡胶组合物生产的充气轮胎。
• IMIDAZOLYLKETONE DERIVATIVES ASD ALDOSTERONE SYNTHASE INHIBITORS
  申请人：F. Hoffmann-La Roche AG

  公开号：EP2814814B1

  公开（公告）日：2019-05-08
• TIRE MEMBER AND METHOD FOR MANUFACTURING THE SAME
  申请人：TOYO TIRE & RUBBER CO., LTD.

  公开号：US20140128525A1

  公开（公告）日：2014-05-08

  A method for manufacturing a tire member, containing a step (A) for producing a mixture containing a diene rubber component, an inorganic filler, a peptizer and a thiosulfuric acid compound containing an amino group, and a step (B) for mixing the mixture, a sulfur component and a vulcanization accelerator, wherein a tire member having improved abrasion resistance, tear strength and flex fatigue resistance is obtained, and the tire member are provided. A premix containing 100 parts by mass of the diene rubber component, from 0.1 to 0.5 parts by mass of the peptizer and 0.2 parts by mass or more of the thiosulfuric acid compound containing an amino group, obtained under a condition in which a temperature during mixing is maintained within a range of from 145 to 170° C. for 20 seconds or more and a temperature at completion of the mixing is 170° C. or lower.