2-(3-(t-butoxycarbonylamino)-5-chloro-6-methyl-2-oxopyrazin-1(2H)-yl)-2-(4-methoxyphenyl)-acetic acid methyl ester | 1251932-99-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-(3-(t-butoxycarbonylamino)-5-chloro-6-methyl-2-oxopyrazin-1(2H)-yl)-2-(4-methoxyphenyl)-acetic acid methyl ester
• CAS: 1251932-99-6
• 化学式: C₂₀H₂₄ClN₃O₆
• 分子量: 437.88
• InChiKey: ZYQLDYQXEQBLQY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.32
• 重原子数：
  30.0
• 可旋转键数：
  5.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  108.75
• 氢给体数：
  1.0
• 氢受体数：
  8.0

反应信息

• 作为反应物：
  描述：

  2-(3-(t-butoxycarbonylamino)-5-chloro-6-methyl-2-oxopyrazin-1(2H)-yl)-2-(4-methoxyphenyl)-acetic acid methyl ester 在 水 、 lithium hydroxide 、 盐酸 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 6.5h， 生成
  参考文献：
  名称：

  Discovery of achiral inhibitors of the hepatitis C virus NS3 protease based on 2(1H)-pyrazinones

  摘要：

  Herein, the design, synthesis and inhibitory potency of a series of novel hepatitis C virus (HCV) NS3 protease inhibitors are presented. These inhibitors are based on a 2(1H)-pyrazinone P3 scaffold in combination with either a P2 phenylglycine or a glycine, and they were evaluated on the wild type as well as on two resistant variants of the enzyme, A156T and D168V. Molecular modelling suggested that the aromatic side-chain of the P2 phenylglycine occupies the same space as the substituent in position 6 on the pyrazinone core. The versatile synthetic route applied for the pyrazinone synthesis made a switch between the two positions easily feasible, resulting in phenyl-or benzyl substituted pyrazinones and leaving glycine as the P2 residue. Of several P1-P1' residues evaluated, an aromatic P1-P1' scaffold was found superior in combination with the new P3-P2 building block. As a result, an entirely new type of achiral and rigidified inhibitors was discovered, with the best of the novel inhibitors having fourfold improved potency compared to the corresponding tripeptide lead. We consider these achiral inhibitors highly suitable as starting points for further optimization. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2010.06.101
• 作为产物：
  描述：

  氨基甲酸叔丁酯 、 2-(3,5-dichloro-6-methyl-2-oxopyrazin-1(2H)-yl)-2-(4-methoxyphenyl)acetic acid methyl ester 在 palladium diacetate 、 caesium carbonate 、 4,5-双二苯基膦-9,9-二甲基氧杂蒽 作用下， 以 乙二醇二甲醚 为溶剂， 反应 47.0h， 以7%的产率得到2-(3-(t-butoxycarbonylamino)-5-chloro-6-methyl-2-oxopyrazin-1(2H)-yl)-2-(4-methoxyphenyl)-acetic acid methyl ester
  参考文献：
  名称：

  Discovery of achiral inhibitors of the hepatitis C virus NS3 protease based on 2(1H)-pyrazinones

  摘要：

  Herein, the design, synthesis and inhibitory potency of a series of novel hepatitis C virus (HCV) NS3 protease inhibitors are presented. These inhibitors are based on a 2(1H)-pyrazinone P3 scaffold in combination with either a P2 phenylglycine or a glycine, and they were evaluated on the wild type as well as on two resistant variants of the enzyme, A156T and D168V. Molecular modelling suggested that the aromatic side-chain of the P2 phenylglycine occupies the same space as the substituent in position 6 on the pyrazinone core. The versatile synthetic route applied for the pyrazinone synthesis made a switch between the two positions easily feasible, resulting in phenyl-or benzyl substituted pyrazinones and leaving glycine as the P2 residue. Of several P1-P1' residues evaluated, an aromatic P1-P1' scaffold was found superior in combination with the new P3-P2 building block. As a result, an entirely new type of achiral and rigidified inhibitors was discovered, with the best of the novel inhibitors having fourfold improved potency compared to the corresponding tripeptide lead. We consider these achiral inhibitors highly suitable as starting points for further optimization. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2010.06.101