2-(4-acetamidocyclohexyl)acetic acid | 2901-45-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-(4-acetamidocyclohexyl)acetic acid
• 英文别名: (cis-4-acetylamino-cyclohexyl)-acetic acid；(cis-4-Acetamino-cyclohexyl)-essigsaeure；cis-4-(Acetylamino)-cyclohexanessigsaeure；cis-N-Acetyl-4-aminocyclohexylessigsaeure
• CAS: 2901-45-3
• 化学式: C₁₀H₁₇NO₃
• 分子量: 199.25
• InChiKey: WFVBDJQHTIBXHZ-DTORHVGOSA-N

物化性质

• 沸点：
  441.1±14.0 °C(Predicted)
• 密度：
  1.13±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.16
• 重原子数：
  14.0
• 可旋转键数：
  3.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  66.4
• 氢给体数：
  2.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  2-(4-acetamidocyclohexyl)acetic acid 在 盐酸 作用下， 生成 (cis-4-amino-cyclohexyl)-acetic acid
  参考文献：
  名称：

  Synthesis of analogs of N-(2-chloroethyl)-N'-(trans-4-methylcyclohexyl)-N-nitrosourea for evaluation as anticancer agents

  摘要：

  The superior activity of N-(2-chloroethyl)-N'-(trans-4-methylcyclohexyl)-N-nitrosourea (MeCCNU) against advanced murine Lewis lung carcinoma in comparisons with the cis form and other nitrosoureas prompted the synthesis of a number of MeCCNU analogues, including several cis-trans pairs. The methyl group was replaced by a variety of substituents (CO2H, CH2CO2H, CO2Me, CH2OAc, CH2Cl, OMe); the trans-3-methylcyclohexyl, cis-2-methyl-1,3-dithian-5-yl, cis- and trans-2-methyl-1,3-dithian-5-yl-tetraoxide, and 1-methylhexyl (open-chain) analogues were also prepared. Preliminary tests against murine leukemia L1210 revealed therapeutic indices (ED50/LD10) ranging from 0.26 to 0.79; all but three analogues effected 50% cure rates at nontoxic doses, the open-chain analogue being one of the least active. In terms of therapeutic index, diequatorial (trans-4) isomers were, with one exception, as active as or, in four of the eight examples, somewhat more active than the corresponding axial-equatorial (cis-4) isomers. In this series, four of the five 2-fluoroethyl analogues prepared were clearly inferior to the corresponding 2-chloroethyl analogues.

  DOI：

  10.1021/jm00212a019
• 作为产物：
  描述：

  阿克他利 在 platinum(IV) oxide 氢气 作用下， 以 溶剂黄146 为溶剂， 生成 2-(4-acetamidocyclohexyl)acetic acid 、 2-(4-acetamidocyclohexyl)acetic acid
  参考文献：
  名称：

  Synthesis of analogs of N-(2-chloroethyl)-N'-(trans-4-methylcyclohexyl)-N-nitrosourea for evaluation as anticancer agents

  摘要：

  The superior activity of N-(2-chloroethyl)-N'-(trans-4-methylcyclohexyl)-N-nitrosourea (MeCCNU) against advanced murine Lewis lung carcinoma in comparisons with the cis form and other nitrosoureas prompted the synthesis of a number of MeCCNU analogues, including several cis-trans pairs. The methyl group was replaced by a variety of substituents (CO2H, CH2CO2H, CO2Me, CH2OAc, CH2Cl, OMe); the trans-3-methylcyclohexyl, cis-2-methyl-1,3-dithian-5-yl, cis- and trans-2-methyl-1,3-dithian-5-yl-tetraoxide, and 1-methylhexyl (open-chain) analogues were also prepared. Preliminary tests against murine leukemia L1210 revealed therapeutic indices (ED50/LD10) ranging from 0.26 to 0.79; all but three analogues effected 50% cure rates at nontoxic doses, the open-chain analogue being one of the least active. In terms of therapeutic index, diequatorial (trans-4) isomers were, with one exception, as active as or, in four of the eight examples, somewhat more active than the corresponding axial-equatorial (cis-4) isomers. In this series, four of the five 2-fluoroethyl analogues prepared were clearly inferior to the corresponding 2-chloroethyl analogues.

  DOI：

  10.1021/jm00212a019

文献信息

• BENZOISOTHIAZOLE COMPOUNDS AND USE IN PREPARATION OF ANTIPSYCHOTIC DRUGS
  申请人：SHANAGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY

  公开号：US20160096811A1

  公开（公告）日：2016-04-07

  Disclosed are benzoisothiazole compounds and a use in the preparation of anti-schizophrenia drugs. The benzoisothiazole compounds of the present invention not only have strong affinity for dopamine D 3 receptor, 5-HT 1A receptor and 5-HT 2A receptor, but also can observably improve the symptoms of schizophrenia relevant to apomorphine model and MK-801 model mice, with oral absorption being good, safety being high and side-effect being less, and having developmental value as new anti-neurotic disease drugs. The present invention is the compounds having a structure of general formula (I), or geometric isomers, free alkalies, salts, hydrates or solvates thereof.

  本发明涉及苯并异噻唑化合物及其在制备抗精神分裂症药物中的应用。本发明的苯并异噻唑化合物不仅具有与多巴胺D3受体、5-HT1A受体和5-HT2A受体的强亲和力，而且可以明显改善与阿泼吗啡模型和MK-801模型小鼠相关的精神分裂症症状，口服吸收良好，安全性高，副作用少，并具有作为新型抗神经症药物的开发价值。本发明是具有通式（I）结构的化合物，或其几何异构体、自由碱、盐、水合物或溶剂化物。
• [EN] CYCLOHEXANE AMINE COMPOUND AND APPLICATION THEREOF FOR ANTI-SCHIZOPHRENIA DRUGS<br/>[FR] COMPOSÉ CYCLOHEXANE AMINE ET SON APPLICATION POUR DES MÉDICAMENTS ANTI-SCHIZOPHRÉNIE
  申请人：JIANGSU HENGYI PHARMACEUTICAL CO LTD

  公开号：WO2014086098A1

  公开（公告）日：2014-06-12

  本发明公开了一种环己烷胺类化合物及其作为抗精神分裂症药物的应用，本发明的环己烷胺类化合物，对多巴胺D3受体和5-ΗΤ1Α有较高的亲和力，且代表化合物具有D3/D2受体高度选择性。体内试验表明，I-1等代表化合物能显著改善阿朴吗啡模型、MK-801模型小鼠的相关症状。本发明涉及的化合物具有良好的抗精神分裂症作用，其急性毒性较低，安全性较高，具有作为高效低毒新型抗精神神经性疾病新药的开发价值。所述环己烷胺类化合物为具有如结构通式（I）所示的化合物或其几何异构体、游离碱、水合物或盐。
• Ferber; Bendix, Chemische Berichte, 1939, vol. 72, p. 839,847
  作者：Ferber、Bendix

  DOI：——

  日期：——
• EP2995617A1
  申请人：——

  公开号：EP2995617A1

  公开（公告）日：2016-03-16
• US9550741B2
  申请人：——

  公开号：US9550741B2

  公开（公告）日：2017-01-24