| 1059566-29-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• CAS: 1059566-29-8
• 化学式: C₁₁H₁₀N₂O₃S
• 分子量: 250.278
• InChiKey: WZIQVZXCKBQPHK-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  (7-methanesulfonylamino-1,1-dioxo-1,4-dihydro-1λ⁶-benzo[1,4]thiazin-3-yl)-acetic acid ethyl ester 、 在 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 反应 0.5h， 生成 N-[3-[2-(cyclopropylmethyl)-5-hydroxy-3-oxo-6-(2-thienyl)pyridazin-4-yl]-1,1-dioxo-4H-1$l^{6},4-benzothiazin-7-yl]methanesulfonamide
  参考文献：
  名称：

  4-(1,1-Dioxo-1,4-dihydro-1λ6-benzo[1,4]thiazin-3-yl)-5-hydroxy-2H-pyridazin-3-ones as potent inhibitors of HCV NS5B polymerase

  摘要：

  4-(1,1-Dioxo-1,4-dihydro-1lambda(6)-benzo[1,4]thiazin-3-yl)-5-hydroxy-2H-pyridazin-3-one analogs were discovered as a novel class of inhibitors of HCV NS5B polymerase. Structure-based design led to the identification of compound 3a that displayed potent inhibitory activities in biochemical and replicon assays (1b IC(50)<10 nM; 1b EC(50)=1.1 nM) as well as good stability toward human liver microsomes (HLM t(1/2)>60 min).

  DOI：

  10.1016/j.bmcl.2008.07.014