tert-butyl 2-(N-(((9H-fluoren-9-yl)methoxy)carbonyl)-N-methyl-L-isoleucyl)hydrazine-1-carboxylate | 1295298-88-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: tert-butyl 2-(N-(((9H-fluoren-9-yl)methoxy)carbonyl)-N-methyl-L-isoleucyl)hydrazine-1-carboxylate
• CAS: 1295298-88-2
• 化学式: C₂₇H₃₅N₃O₅
• 分子量: 481.592
• InChiKey: ACCOPJLGIAUGNL-SBUREZEXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.84
• 重原子数：
  35.0
• 可旋转键数：
  6.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  96.97
• 氢给体数：
  2.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  tert-butyl 2-(N-(((9H-fluoren-9-yl)methoxy)carbonyl)-N-methyl-L-isoleucyl)hydrazine-1-carboxylate 、 溴乙酰溴 在 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成
  参考文献：
  名称：

  Sugar amino acid based peptide epoxyketones as potential proteasome inhibitors

  摘要：

  This paper describes the synthesis and biological evaluation of nine epoxomicin-derived sugar amino acid containing peptide epoxyketones. The title compounds are assembled from six sugar amino acid dipeptide isosteres and are synthesized using solution-phase peptide synthesis protocols. Although neither of the compounds displays inhibitory activity towards any of the proteasome active sites, our approach holds promise towards the development of structurally new proteasome inhibitors. It is likely that the central sugar amino acid dipeptide isoster needs to be designed such that it closely resemble dipeptides at position P2 and P3 in proteasome substrates inhibitors, such as the Thr-Ile dipeptide present in the lead compound, epoxomicin. (C) 2010 Elsevier Inc. All rights reserved.

  DOI：

  10.1016/j.bioorg.2010.04.004
• 作为产物：
  描述：

  肼基甲酸叔丁酯 、 Fmoc-N-甲基-L-异亮氨酸 在 6-chloro-3-((dimethylamino)(dimethyliminio)methyl)-1H-benzo[d][1,2,3]triazol-3-ium-1-olatehexafluorophosphate(V) 、 N,N-二异丙基乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 4.0h， 以86%的产率得到tert-butyl 2-(N-(((9H-fluoren-9-yl)methoxy)carbonyl)-N-methyl-L-isoleucyl)hydrazine-1-carboxylate
  参考文献：
  名称：

  Sugar amino acid based peptide epoxyketones as potential proteasome inhibitors

  摘要：

  This paper describes the synthesis and biological evaluation of nine epoxomicin-derived sugar amino acid containing peptide epoxyketones. The title compounds are assembled from six sugar amino acid dipeptide isosteres and are synthesized using solution-phase peptide synthesis protocols. Although neither of the compounds displays inhibitory activity towards any of the proteasome active sites, our approach holds promise towards the development of structurally new proteasome inhibitors. It is likely that the central sugar amino acid dipeptide isoster needs to be designed such that it closely resemble dipeptides at position P2 and P3 in proteasome substrates inhibitors, such as the Thr-Ile dipeptide present in the lead compound, epoxomicin. (C) 2010 Elsevier Inc. All rights reserved.

  DOI：

  10.1016/j.bioorg.2010.04.004