5-(Methoxymethyl)isoxazole-3-carbaldehyde | 893749-91-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5-(Methoxymethyl)isoxazole-3-carbaldehyde
• 英文别名: 5-(methoxymethyl)-1,2-oxazole-3-carbaldehyde
• CAS: 893749-91-2
• 化学式: C₆H₇NO₃
• mdl: MFCD06804221
• 分子量: 141.12
• InChiKey: ZJIQQPKTXCFQBB-UHFFFAOYSA-N

物化性质

• 沸点：
  247.0±30.0 °C(Predicted)
• 密度：
  1.213±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  52.3
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• INHIBITORS OF APOL1 AND METHODS OF USING SAME
  申请人：Vertex Pharmaceuticals Incorporated

  公开号：US20220106327A1

  公开（公告）日：2022-04-07

  The disclosure provides at least one entity chosen from compounds of Formula I, a tautomer thereof, a deuterated derivative of that compound or tautomer, and a pharmaceutically acceptable salt of any of the foregoing, compositions comprising the same, and methods of using the same, including uses in treating APOL1-mediated diseases, including pancreatic cancer, focal segmental glomerulosclerosis (FSGS), and/or non-diabetic kidney disease (NDKD).