Cyclopent-3-en-2-on-1-yl-essigsaeure | 22060-61-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Cyclopent-3-en-2-on-1-yl-essigsaeure
• 英文别名: 4-Hydroxycarbonylmethylcyclopent-2-enon；2-Oxo-cyclopenten-(3)-yl-(1)-essigsaeure；2-Oxocyclopent-3-enyl-acetic acid；2-(2-oxocyclopent-3-en-1-yl)acetic acid
• CAS: 22060-61-3
• 化学式: C₇H₈O₃
• mdl: MFCD19228782
• 分子量: 140.139
• InChiKey: XHJLITCMYMKIIX-UHFFFAOYSA-N

物化性质

• 熔点：
  52-54 °C
• 沸点：
  339.5±21.0 °C(Predicted)
• 密度：
  1.265±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.428
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-(2-Hydroxy-2-propyl)-2-oxa-3-oxobicyclo<3.3.0>oct-7-ene 、 lead(IV) acetate 生成 Cyclopent-3-en-2-on-1-yl-essigsaeure
  参考文献：
  名称：

  OKU, AKIRA;NOZAKI, YOHKO;HASEGAWA, HIROSHI;NISHIMURA, JUN;HARADA, TOSHIRO, J. ORG. CHEM., 1983, 48, N 23, 4374-4377

  摘要：

  DOI：

文献信息

• ARGINASE INHIBITORS AND THEIR THERAPEUTIC APPLICATIONS
  申请人：Oncoarendi Therapeutics SA

  公开号：EP3452485A2

  公开（公告）日：2019-03-13
• 1-OXO-1,2-DIHYDROISOQUINOLIN-7-YL-(5-SUBSTITUTED-THIOPHEN-2-YL)-SULFONAMIDE COMPOUNDS, FORMULATIONS CONTAINING THOSE COMPOUNDS, AND THEIR USE AS AICARFT INHIBITORS IN THE TREATMENT OF CANCERS
  申请人：Eli Lilly and Company

  公开号：US20170233378A1

  公开（公告）日：2017-08-17

  1-Oxo-1,2-dihydroisoquinolin-7-yl-(5-substituted-thiophen-2-yl)-sulfonamide compounds, formulations containing those compounds, and their use as AICARFT inhibitors.
• [EN] ARGINASE INHIBITORS AND THEIR THERAPEUTIC APPLICATIONS<br/>[FR] INHIBITEURS D'ARGINASE ET LEURS APPLICATIONS THÉRAPEUTIQUES
  申请人：ONCOARENDI THERAPEUTICS SA

  公开号：WO2017191130A2

  公开（公告）日：2017-11-09

  Disclosed are small molecule therapeutic compounds that are potent inhibitors of arginase 1 and arginase 2 activity. Also disclosed are pharmaceutical compositions comprising the compounds, and methods for using the compounds for treating or preventing a disease or condition associated with arginase activity.