(1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-2,2'-binaphthyl-5,5'-diyl)bis(benzo[d]thiazol-2-ylmethanone) | 1146624-44-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-2,2'-binaphthyl-5,5'-diyl)bis(benzo[d]thiazol-2-ylmethanone)
• 英文别名: US9115061, Xvii；[6-[5-(1,3-benzothiazole-2-carbonyl)-1,6,7-trihydroxy-3-methylnaphthalen-2-yl]-2,3,5-trihydroxy-7-methylnaphthalen-1-yl]-(1,3-benzothiazol-2-yl)methanone
• CAS: 1146624-44-3
• 化学式: C₃₈H₂₄N₂O₈S₂
• 分子量: 700.749
• InChiKey: YCUCYHOUGDRKQJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10
• 重原子数：
  50
• 可旋转键数：
  5
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  238
• 氢给体数：
  6
• 氢受体数：
  12

文献信息

• NAPHTHALENE-BASED INHIBITORS OF ANTI-APOPTOTIC PROTEINS
  申请人：Pellecchia Maurizio

  公开号：US20090105319A1

  公开（公告）日：2009-04-23

  Methods of using apogossypol and its derivatives for treating inflammation is disclosed. Also, there is described a group of compounds having structure A, or a pharmaceutically acceptable salt, hydrate, N-oxide, or solvate thereof are provided: wherein each R is independently selected from the group consisting of H, C(O)X, C(O)NHX, NH(CO)X, SO 2 NHX, and NHSO 2 X, wherein X is selected from the group consisting of an alkyl, a substituted alkyl, an aryl, a substituted aryl, an alkylaryl, and a heterocycle. Compounds of group A may be used for treating various diseases or disorders, such as cancer.

  使用阿波戈司宝及其衍生物治疗炎症的方法被披露。此外，还描述了一组具有结构A的化合物，或其药学上可接受的盐、水合物、N-氧化物或溶剂化合物： 其中每个R独立地选自H、C(O)X、C(O)NHX、NH(CO)X、SO2NHX和NHSO2X组成的组，其中X选自烷基、取代烷基、芳基、取代芳基、烷基芳基和杂环的组。A组化合物可用于治疗各种疾病或疾病，如癌症。
• Napthalene-Based Inhibitors of Anti-Apoptotic Proteins
  申请人：Pellecchia Maurizio

  公开号：US20120015992A1

  公开（公告）日：2012-01-19

  Methods of using apogossypol and its derivatives for treating inflammation is disclosed. Also, there is described a group of compounds having structure A, or a pharmaceutically acceptable salt, hydrate, N-oxide, or solvate thereof are provided: wherein each R is independently H, C(O)X, C(O)NHX, NH(CO)X, SO 2 NHX, or NHSO 2 X, wherein X is hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, alkylaryl, substituted alkylaryl, heterocycle, or substituted heterocycle. Compounds of group A may be used for treating various diseases or disorders, such as cancer.

  本文披露了使用阿泊果酚及其衍生物治疗炎症的方法。此外，还提供了一组具有结构A的化合物，或其药学上可接受的盐、水合物、N-氧化物或溶剂化物：其中每个R独立地为H、C（O）X、C（O）NHX、NH（CO）X、SO2NHX或NHSO2X，其中X为氢、烷基、取代烷基、芳基、取代芳基、烷基芳基、取代烷基芳基、杂环或取代杂环。A组化合物可用于治疗各种疾病或疾病，如癌症。
• US8039668B2
  申请人：——

  公开号：US8039668B2

  公开（公告）日：2011-10-18
• US8436207B2
  申请人：——

  公开号：US8436207B2

  公开（公告）日：2013-05-07
• US9115061B2
  申请人：——

  公开号：US9115061B2

  公开（公告）日：2015-08-25