(2R,3S,4S,5R,6S)-5-Chloro-2-hydroxymethyl-6-methoxy-tetrahydro-pyran-3,4-diol | 20513-89-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2R,3S,4S,5R,6S)-5-Chloro-2-hydroxymethyl-6-methoxy-tetrahydro-pyran-3,4-diol
• 英文别名: (2R,3S,4S,5R,6S)-5-chloro-2-(hydroxymethyl)-6-methoxyoxane-3,4-diol
• CAS: 20513-89-7
• 化学式: C₇H₁₃ClO₅
• 分子量: 212.63
• InChiKey: SBBAMKLLVBOARH-GKHCUFPYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.8
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  79.2
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• A method for the preparation of 2-chloro-2-deoxy saccharides and some 2-chloro-2-deoxy saccharides
  申请人：TATE & LYLE PATENT HOLDINGS LIMITED

  公开号：EP0010410A2

  公开（公告）日：1980-04-30

  A process for the preparation of a 2-chloro- 2-deoxy-mono, di- or oligo-saccharide, comprises reaction of a mono-, di- or oligo-sapqharide derivative having a free hydroxy group in at least 2- position and having the hydroxy group in at least the 1 - and 3- positions protected from chlorination, with sulphuryl chloride in the presence of an organic base in a chlorinated hydrocarbon solvent at a temperature below -40°C to form a chlorosulphate derivative with a chlorosulphate derivative isthen reacted with lithium chloride in the presence of hexamethylphosphoric triamide to replace chlorosulphate groups with chlorine atoms to form a chlorodeoxy derivative, which chlorodeoxy derivative is then freed of unwanted protecting groups.

  一种制备 2-氯-2-脱氧单糖、双糖或低聚糖的工艺，包括在有机碱存在下，在 氯化烃溶剂中，在低于-40℃的温度下，使至少在 2-位上具有游离羟基和至少在 1-位和 3-位上具有不被氯化保护的羟基的单糖、双糖或低聚糖衍生物与硫酰氯反应，形成氯代硫酸酯衍生物，然后在六甲基三磷酰胺存在下，使氯代硫酸酯衍生物与氯化锂反应，用氯原子取代氯代硫酸酯基团，形成氯代脱氧衍生物，然后使氯代脱氧衍生物摆脱不需要的保护基团。
• US4262115A
  申请人：——

  公开号：US4262115A

  公开（公告）日：1981-04-14