Metabolism of diiodomethyl-p-tolylsulfone (DIMPTS) was investigated in rats to determine the role of iodide in its toxicity. Fischer 344 (F-344) (5 or 50 mg/kg) or Sprague Dawley (SD) (5 mg/kg) rats were gavaged with (14)C-DIMPTS or dermally applied with 5 mg/kg (F-344 only) and absorption, distribution, metabolism and excretion (ADME) determined. ... DIMPTS liberated one or both of its iodine atoms upon absorption. The rate of elimination of the liberated iodide from the systemic circulation was 2- to 3-fold slower in SD than F-344 rats, which resulted in higher bioavailability of iodide to SD rats. DIMPTS was primarily oxidized at the benzylic methyl moiety forming the corresponding benzoic acid. Glutathione conjugation on the sulfonyl methyl group, via displacement of I(-) was also observed. Overall 67-80% of the total iodine atoms were metabolically released from DIMPTS. ...
IDENTIFICATION AND USE: Diiodomethyl p-tolyl sulfone (DIMPTS) is a tan powder at room temperature. It is an algaecide, bactericide, and fungicide. DIMPTS is used as a materials preservative in paints, air duct coatings, fire-retardant coatings, pigment dispersions, inks, emulsions, extender slurries, adhesives, caulks, sealants, rubbers, plastic, textiles, leather, paper production to protect pulp and slurries, paper/paperboard, and wetlap. It is also used as a wood preservative. HUMAN EXPOSURE AND TOXICITY: Corrosive: causes irreversible eye damage. Harmful if absorbed through the skin. ANIMAL STUDIES: Male and female rats and dogs were administered DIMPTS for 90-days via the diet. In rats, the only treatment-related finding was squamous metaplasia of the salivary gland duct in the 80 mg/kg/day group. In dogs, female body weights in the high-dose group were significantly lower than controls. Altered clinical pathology parameters were considered secondary to inflammatory changes observed in some of the dogs. Treatment-related alterations were found in the thyroid glands, salivary glands, GI-tract in the mid- and/or high-dose groups. DIMPTS was negative in the four in vitro and one in vivo genotoxicity assays. The toxicological effects noted in the two mammalian species are consistent with the principal toxic effects of iodide, and are proposed to arise from release of iodide from the DIMPTS molecule with toxic sequelae. DIMPTS caused dystocia, decreased neonatal survival and hypothyroidism in rat reproduction studies resembling the effects caused by iodide. One molecule of DIMPTS contains two iodine moieties that are hydrolyzed upon ingestion and systemically absorbed, suggesting iodide toxicity as a probable mode of action for the effects observed in rats. Female rats given DIMPTS had increased incidence of vulvar discharge and dystocia, decreased litter size, decreased body weights and feed consumption, increased thyroid weights, thyroid follicular cell hypertrophy with decreased colloid, decreased triiodothyronine, and increased thyroid stimulating hormone levels. DIMPTS pups had decreased neonatal survival and body weights. These effects were associated with elevated levels of iodide in milk and sera. In contrast, DIMPTS de-iodinated analogue did not produce similar effects in adult females or their offspring. In rats reproductive toxicity at 40 mg/kg/day consisted of increased post implantation loss, decreased gestation survival and two cases of dystocia, while litter size, pup survival/weight were affected at 10 and 40 mg/kg/day. Morphological examinations of fetuses revealed no evidence of teratogenesis.
来源:Hazardous Substances Data Bank (HSDB)
毒理性
毒性数据
大鼠LC50 = 960毫克/立方米/4小时
LC50 (rat) = 960 mg/m3/4hr
来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Poisons A and B/
Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Cover skin burns with dry sterile dressings after decontamination ... . /Poisons A and B/
Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag-valve-mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Consider administering a beta agonist such as albuterol for severe bronchospasm ... . Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start IV administration of D5W TKO. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam (Valium) or lorazepam (Ativan) ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Poisons A and B/
Metabolism of diiodomethyl-p-tolylsulfone (DIMPTS) was investigated in rats to determine the role of iodide in its toxicity. Fischer 344 (F-344) (5 or 50 mg/kg) or Sprague Dawley (SD) (5 mg/kg) rats were gavaged with (14)C-DIMPTS or dermally applied with 5 mg/kg (F-344 only) and absorption, distribution, metabolism and excretion (ADME) determined. Additional experiments were conducted with its deiodinated analog (methyl-p-tolylsulfone, MPTS) in female F-344 rats (20 mg/kg) for comparison. Orally administered (14)C-DIMPTS was rapidly absorbed and eliminated in urine (92%). ... Dermally applied (14)C-DIMPTS remained undetectable in plasma with bioavailability approxamately 7%, only 5-7% of the dose was recovered in urine. ... The MPTS was rapidly absorbed from the GI tract, metabolized and eliminated in urine similar to that of DIMPTS. ...
[EN] IMPROVED CORROSION AND MICROBIAL CONTROL IN HYDROCARBONACEOUS COMPOSITIONS<br/>[FR] LUTTE AMÉLIORÉE CONTRE LA CORROSION ET CONTRE LES MICROBES DANS DES COMPOSITIONS HYDROCARBONÉES
申请人：ANGUS CHEMICAL
公开号：WO2009140062A1
公开（公告）日：2009-11-19
Provided are additives of formula I for use in hydrocarbonaceous compositions, such as petroleum or liquid fuels: (I) wherein R1, R2, R3, R4, and R5 are as defined herein. The additives improve the corrosion resistance of the compositions. The additives also enhance the antimicrobial efficacy of any added biocides contained in such compositions.
Die Verbindungen der Formel (I), in welcher R1 für Wasserstoff oder jeweils gegebenenfalls substituiertes Alkyl, Alkenyl, Alkinyl oder Phenyl steht, eignen sich hervorragend als Mikrobizide zum Schutz von Pflanzen und Materialien.
The invention relates to novel triazolopyrimidines of the formula
1
wherein
X represents halogen,
Y represents a hydrogen atom or halogen, and
R has the meanings given in the disclosure,
to a process for the preparation of the new compounds, and to their use as microbicides.
Heterocylic fluoroalkenyl thioethers and the use thereof as pesticides (IV)
申请人：——
公开号：US20030187259A1
公开（公告）日：2003-10-02
The present invention relates to novel heterocyclic fluoroalkenyl thioethers of the formula (I)
1
in which
m represents integers from 3 to 10,
n represents 0, 1 or 2 and
Het represents the following, in each case optionally substituted, groupings:
2
and to processes for their preparation and to their use as pesticides.
Use of riboflavin and flavin derivatives as chitinase inhibitors
申请人：——
公开号：US20030191091A1
公开（公告）日：2003-10-09
The invention relates to the use of riboflavin and of flavin derivatives with chitinase-inhibitory action for controlling arthropods, nematodes and chitin-containing fungi.
