2-amino-7-β-(D-ribofuranosyl)-furo [3,2-d]pyrimidin-4(3H)-one | 885653-98-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-amino-7-β-(D-ribofuranosyl)-furo [3,2-d]pyrimidin-4(3H)-one
• 英文别名: 2-amino-7-[(2S,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-furo[3,2-d]pyrimidin-4-one
• CAS: 885653-98-5
• 化学式: C₁₁H₁₃N₃O₆
• 分子量: 283.241
• InChiKey: NWWHKXUPEPVTOX-JBBNEOJLSA-N

物化性质

• 沸点：
  602.4±65.0 °C(Predicted)
• 密度：
  2.13±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -2.3
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  151
• 氢给体数：
  5
• 氢受体数：
  6

文献信息

• Therapeutic Furopyrimidines and Thienopyrimidines
  申请人：Babu Yarlagadda S.

  公开号：US20080300200A1

  公开（公告）日：2008-12-04

  The invention provides compounds of formula I, II, and III as described herein, as well as pharmaceutical compositions comprising the compounds, and synthetic methods and intermediates that are useful for preparing the compounds. The compounds of formula I, II, and III are useful as anti-viral agents and/or as anti-cancer agents.

  本发明提供了公式I、II和III所描述的化合物，以及包含这些化合物的药物组合物，以及用于制备这些化合物的合成方法和中间体。公式I、II和III的化合物可用作抗病毒剂和/或抗癌剂。
• METHODS FOR THE PREPARATION OF 9-DEAZAPURINE DERIVATIVES
  申请人：Chand Pooran

  公开号：US20100093991A1

  公开（公告）日：2010-04-15

  Methods for the preparation of the β isomer of a 9-deazapurine derivatives using benzyl protecting groups as the protecting groups for the 2 and 3 hydroxyl groups in ribose are provided.

  本文提供了一种使用苄基保护基作为核糖中2和3羟基的保护基来制备9-脱氮嘌呤衍生物β异构体的方法。
• THERAPEUTIC FUROPYRIMIDINES AND THIENOPYRIMIDINES
  申请人：Babu Yarlagadda S.

  公开号：US20120213735A1

  公开（公告）日：2012-08-23

  The invention provides compounds of formula I, II, and III as described herein, as well as pharmaceutical compositions comprising the compounds, and synthetic methods and intermediates that are useful for preparing the compounds. The compounds of formula I, II, and III are useful as anti-viral agents and/or as anti-cancer agents.

  本发明提供了式I、II和III的化合物，以及包含该化合物的药物组合物，以及用于制备该化合物的合成方法和中间体。式I、II和III的化合物可用作抗病毒剂和/或抗癌剂。
• Hepatics C therapies
  申请人：Biocryst Pharmaceuticals, Inc.

  公开号：EP2537520A1

  公开（公告）日：2012-12-26

  The invention provides methods for treating hepatitis C viral infections and related viral infections, as well as compounds and compositions that are useful for treating such infections

  本发明提供了治疗丙型肝炎病毒感染和相关病毒感染的方法，以及可用于治疗此类感染的化合物和组合物
• Hepatitis C therapies
  申请人：Babu S. Yarlagadda

  公开号：US20060234963A1

  公开（公告）日：2006-10-19

  The invention provides methods for treating hepatitis C viral infections and related viral infections, as well as compounds and compositions that are useful for treating such infections.