N-(4-((6,7-dimethoxyquinolin-4-yl)oxy)-2-fluorophenyl)cyclopropanesulfonamide | 1192298-35-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N-(4-((6,7-dimethoxyquinolin-4-yl)oxy)-2-fluorophenyl)cyclopropanesulfonamide
• 英文别名: cyclopropanesulfonic acid [4-(6,7-dimethoxyquinolin-4-yloxy)-2-fluorophenyl]amide；N-[4-(6,7-dimethoxyquinolin-4-yl)oxy-2-fluorophenyl]cyclopropanesulfonamide
• CAS: 1192298-35-3
• 化学式: C₂₀H₁₉FN₂O₅S
• 分子量: 418.446
• InChiKey: INDVIGKBCHMOCM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  29
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  95.1
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• [EN] ECTONUCLEOTIDE PYROPHOSPHATASE-PHOSPHODIESTERASE 1 (ENPP-1) INHIBITORS AND USES THEREOF<br/>[FR] INHIBITEURS DE L'ECTONUCLÉOTIDE PYROPHOSPHATASE-PHOSPHODIESTÉRASE (ENPP-1) ET UTILISATIONS DE CES DERNIERS
  申请人：MAVUPHARMA INC

  公开号：WO2019046778A1

  公开（公告）日：2019-03-07

  Disclosed herein are methods and compounds of augmenting and enhancing the production of type I IFNs in vivo. In some embodiments, the compounds disclosed herein are ENPP-1 inhibitors, pharmaceutical compositions, and methods for the treatment of cancer or a viral infection.

  本文揭示了一种增强和促进体内I型干扰素产生的方法和化合物。在某些实施例中，本文所披露的化合物是ENPP-1抑制剂，药物组合物，以及用于治疗癌症或病毒感染的方法。
• [EN] QUINOLINE DERIVATIVES AS AXL KINASE INHIBITORS<br/>[FR] DÉRIVÉS DE QUINOLINES UTILISÉS COMME INHIBITEURS DES KINASES AXL
  申请人：MAX PLANCK GESELLSCHAFT

  公开号：WO2009127417A1

  公开（公告）日：2009-10-22

  The present invention relates to novel compounds which are inhibitors of receptor tyrosine kinases of the AXL receptor family. These compounds are suitable for the treatment or prevention of disorders associated with, accompanied by or caused by hyperfunction of a receptor of the AXL family. The compounds are suitable for the treatment of hyperproliferative disorders, such as cancer, particularly cancer metastases.

  本发明涉及一种新型化合物，它们是AXL受体家族的受体酪氨酸激酶抑制剂。这些化合物适用于治疗或预防与AXL家族受体的受体功能亢进相关、伴随或引起的疾病。这些化合物适用于治疗增生性疾病，如癌症，特别是癌症转移。
• QUINOLINE DERIVATIVES AS AXL KINASE INHIBITORS
  申请人：Ullrich Axel

  公开号：US20110092503A1

  公开（公告）日：2011-04-21

  Novel compounds which are inhibitors of receptor tyrosine kinases of the AXL receptor family are described herein. These compounds are suitable for the treatment or prevention of disorders associated with, accompanied by or caused by hyperfunction of a receptor of the AXL family. The compounds are suitable for the treatment of hyperproliferative disorders, such as cancer, particularly cancer metastases.

  本文介绍了一种抑制AXL受体家族的受体酪氨酸激酶的新型化合物。这些化合物适用于治疗或预防与AXL家族受体的受体高功能相关、伴随或引起的疾病。这些化合物适用于治疗增生性疾病，如癌症，特别是癌症转移。
• ECTONUCLEOTIDE PYROPHOSPHATASE-PHOSPHODIESTERASE 1 (ENPP-1) INHIBITORS AND USES THEREOF
  申请人：AbbVie Inc.

  公开号：US20200291024A1

  公开（公告）日：2020-09-17

  Disclosed herein are methods and compounds of augmenting and enhancing the production of type I IFNs in vivo. In some embodiments, the compounds disclosed herein are ENPP-1 inhibitors, pharmaceutical compositions, and methods for the treatment of cancer or a viral infection.
• US9206130B2
  申请人：——

  公开号：US9206130B2

  公开（公告）日：2015-12-08