ω-(4-Fluorphenoxy)-p-methylacetophenon | 50618-35-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: ω-(4-Fluorphenoxy)-p-methylacetophenon
• 英文别名: ω-(4-fluorophenoxy)-p-methylacetophenone；omega-(4-Fluorophenoxy)-p-methylacetophenone；2-(4-fluorophenoxy)-1-(4-methylphenyl)ethanone
• CAS: 50618-35-4
• 化学式: C₁₅H₁₃FO₂
• mdl: MFCD01798408
• 分子量: 244.265
• InChiKey: TYLIAPVOZKLSDV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.133
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  ω-(4-Fluorphenoxy)-p-methylacetophenon 生成 5-fluoro-2-(p-tolyl)benzofuran
  参考文献：
  名称：

  Compounds including carboxystyrylphenyl group

  摘要：

  苯并呋喃、苯并噻吩和萘并呋喃，它们被羧基苯乙烯基苯基取代，以及它们对应的酯和酰胺是一种光学增白剂，可用于美白和增亮天然和合成纤维、纸张、树脂等。这些化合物可通过苯并呋喃、苯并噻吩或萘并呋喃与芳香醛或最好是其苯胺衍生物相互作用方便地制备。

  公开号：

  US03974144A1
• 作为产物：
  描述：

  4-氟苯酚 、 2-溴-4'-甲基苯乙酮 在 potassium carbonate 作用下， 以 丁酮 为溶剂， 反应 3.0h， 以76%的产率得到ω-(4-Fluorphenoxy)-p-methylacetophenon
  参考文献：
  名称：

  Synthesis and calcium antagonistic activity of a series of diethyl benzofuryl, benzothienyl and benzogammapyronyl benzylphosphonates

  摘要：

  In this work we present about 15 original heterocyclic diethyl benzylphosphonate analogues of fostedil, in which we have varied the nature of the heterocycle, the substituents or the phosphonic group, or even the position of this latter. Three diethyl 4-(2-benzofuryl) benzyl phosphonates exhibited slightly higher calcium antagonism than the control. Solely substitution with a fluorine atom was able to maintain activity, whereas the other modifications always decreased it.

  DOI：

  10.1016/0223-5234(93)90084-r

文献信息

• Compounds including carboxystyrylphenyl group
  申请人：Sterling Drug Inc.

  公开号：US03974144A1

  公开（公告）日：1976-08-10

  Benzofurans, benzothiophenes, and naphthofurans which are substituted by carboxystyrylphenyl groups and their corresponding esters and amides are optical brightening agents useful for whitening and brightening natural and synthetic fibers, papers, resins and the like. The compounds are conveniently prepared by interacting benzofurans, benzothiophenes or naphthofurans, which are substituted by a p-tolyl group, with an aromatic aldehyde or preferably the anil derivative thereof.

  苯并呋喃、苯并噻吩和萘并呋喃，它们被羧基苯乙烯基苯基取代，以及它们对应的酯和酰胺是一种光学增白剂，可用于美白和增亮天然和合成纤维、纸张、树脂等。这些化合物可通过苯并呋喃、苯并噻吩或萘并呋喃与芳香醛或最好是其苯胺衍生物相互作用方便地制备。
• US3974144A
  申请人：——

  公开号：US3974144A

  公开（公告）日：1976-08-10
• Synthesis and calcium antagonistic activity of a series of diethyl benzofuryl, benzothienyl and benzogammapyronyl benzylphosphonates
  作者：G Baziard-Mouysset、GW Tchani、JL Stigliani、M Payard、R Bonnafous、J Tisne-Versailles

  DOI：10.1016/0223-5234(93)90084-r

  日期：1993.1

  In this work we present about 15 original heterocyclic diethyl benzylphosphonate analogues of fostedil, in which we have varied the nature of the heterocycle, the substituents or the phosphonic group, or even the position of this latter. Three diethyl 4-(2-benzofuryl) benzyl phosphonates exhibited slightly higher calcium antagonism than the control. Solely substitution with a fluorine atom was able to maintain activity, whereas the other modifications always decreased it.