(S)-2-Hexylcarbamoyl-pyrrolidine-1-carboxylic acid benzyl ester | 55647-41-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (S)-2-Hexylcarbamoyl-pyrrolidine-1-carboxylic acid benzyl ester
• CAS: 55647-41-1
• 化学式: C₁₉H₂₈N₂O₃
• 分子量: 332.443
• InChiKey: OCRAYFRJUIGFLT-KRWDZBQOSA-N

反应信息

• 作为反应物：
  描述：

  (S)-2-Hexylcarbamoyl-pyrrolidine-1-carboxylic acid benzyl ester 在 氢溴酸 、 溶剂黄146 作用下， 反应 3.0h， 生成 (S)-2-(hexylcarbamoyl)pyrrolidinium bromide
  参考文献：
  名称：

  Small organic molecule catalyzed enantioselective direct aldol reaction in water

  摘要：

  Protonated pyrrolidine based small organic molecules have been designed and evaluated for the asymmetric direct aldol reaction in water. The designed organocatalysts are multifunctional in nature and exploit the combined effect of hydrogen bonding and hydrophobic interactions for enantioselective catalysis in water. As a result a unique direct asymmetric aldol reaction in water catalyzed by a small organic molecule having an amide linkage has been developed. The developed catalyst affords chiral beta-hydroxyketones in good yields (93%) and enantioselectivities (upto 62%) in water. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2006.07.016
• 作为产物：
  描述：

  正己胺 、 N-苄氧羰基-L-脯氨酸 在 N,N'-二环己基碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 生成 (S)-2-Hexylcarbamoyl-pyrrolidine-1-carboxylic acid benzyl ester
  参考文献：
  名称：

  Small organic molecule catalyzed enantioselective direct aldol reaction in water

  摘要：

  Protonated pyrrolidine based small organic molecules have been designed and evaluated for the asymmetric direct aldol reaction in water. The designed organocatalysts are multifunctional in nature and exploit the combined effect of hydrogen bonding and hydrophobic interactions for enantioselective catalysis in water. As a result a unique direct asymmetric aldol reaction in water catalyzed by a small organic molecule having an amide linkage has been developed. The developed catalyst affords chiral beta-hydroxyketones in good yields (93%) and enantioselectivities (upto 62%) in water. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2006.07.016