6-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-6-yloxy)-N-hydroxyhexanamide | 1021360-72-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 6-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-6-yloxy)-N-hydroxyhexanamide
• 英文别名: 6-[4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-6-yl]oxy-N-hydroxyhexanamide
• CAS: 1021360-72-4
• 化学式: C₃₀H₃₆FN₅O₅
• 分子量: 565.645
• InChiKey: LUWVVUWJLSELFA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  41
• 可旋转键数：
  14
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  122
• 氢给体数：
  3
• 氢受体数：
  9

文献信息

• VEGFR INHIBITORS CONTAINING A ZINC BINDING MOIETY
  申请人：Qian Changgeng

  公开号：US20090076044A1

  公开（公告）日：2009-03-19

  The present invention relates to VEGFR inhibitors and their use in the treatment of cell proliferative diseases such as cancer. The said derivatives may further act as HDAC inhibitors.

  本发明涉及VEGFR抑制剂及其在治疗细胞增殖性疾病如癌症中的应用。所述衍生物还可能作为HDAC抑制剂。
• [EN] VEGFR INHIBITORS CONTAINING A ZINC BINDING MOIETY<br/>[FR] INHIBITEURS DE VEGFR CONTENANT UNE FRACTION DE LIAISON AU ZINC
  申请人：CURIS INC

  公开号：WO2009036055A1

  公开（公告）日：2009-03-19

  The present invention relates to VEGFR inhibitors and their use in the treatment of cell proliferative diseases such as cancer. The said derivatives may further act as HDAC inhibitors.