6-methoxy-2,2-dimethyl-3H-oxasilin-4-one | 130573-45-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 6-methoxy-2,2-dimethyl-3H-oxasilin-4-one
• CAS: 130573-45-4
• 化学式: C₇H₁₂O₃Si
• 分子量: 172.256
• InChiKey: FDPKIIJJTYMRGI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.28
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  乙酰乙酸甲酯 生成 6-methoxy-2,2-dimethyl-3H-oxasilin-4-one
  参考文献：
  名称：

  The formal oxidative addition of electron-rich transoid dienes to bromonaphthoquinones

  摘要：

  This work established the idea that a halogen atom, such as bromine, will act as a control element in the regiospecific formation of a new carbon-carbon bond. The addition of the electron-rich end of a transoid diene to a bromojuglone derivative occurred exclusively at the unsubstituted carbon of the quinone. Thus, 2,2-dimethyl-4-methoxy-6-methylene-1,3-dioxa-2-sila-4-cyclohexene (3) and either 2- or 3-bromo-5-hydroxy-1,4-naphthoquinone (1 or 2) afforded the adducts 19 or 20 in 57% or 71% yield. Similarly, 2,2-dimethyl-6-methylene-4-(trimethylsiloxy)-1,3-diox-4-ene (4) and 1 gave 21 in 77% yield.

  DOI：

  10.1021/jo00001a020