| 1069085-14-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• CAS: 1069085-14-8
• 化学式: C₁₅H₁₅N₃O₂S
• 分子量: 301.369
• InChiKey: HJAMEQQGWOOYMX-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  在 溶剂黄146 作用下， 反应 1.0h， 生成 3-Methyl-5-phenyl-11-thia-4,5,7-triazatricyclo[7.3.0.0^{2,6}]dodeca-1(9),2(6),3-trien-8-one
  参考文献：
  名称：

  Identification of ring-fused pyrazolo pyridin-2-ones as novel poly(ADP-ribose)polymerase-1 inhibitors

  摘要：

  A novel class of PARP-1 inhibitors was identified containing a non-aromatic heterocycle or carbocycle fused to a pyrazolo pyridin-2-one. Compounds displayed low nanomolar binding activity in the PARP-1 binding assay and submicromolar activity in a cell based chemosensitization assay. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.07.091
• 作为产物：
  描述：

  5-氨基-3-甲基-1-苯基吡唑 、 alkaline earth salt of/the/ methylsulfuric acid 在 吡啶 作用下， 以 邻二甲苯 为溶剂， 生成
  参考文献：
  名称：

  Identification of ring-fused pyrazolo pyridin-2-ones as novel poly(ADP-ribose)polymerase-1 inhibitors

  摘要：

  A novel class of PARP-1 inhibitors was identified containing a non-aromatic heterocycle or carbocycle fused to a pyrazolo pyridin-2-one. Compounds displayed low nanomolar binding activity in the PARP-1 binding assay and submicromolar activity in a cell based chemosensitization assay. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.07.091